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Gene

HECTD4

HECT domain E3 ubiquitin protein ligase 4

Summary

Cytogenetic location
12q24.13
Coordinates
Chromosome 12: 112,160,195–112,382,431 (GRCh38)
Exons
76 exons across 222.2 kb
Protein
4,418 amino acids
Also known as
FLJ34154, KIAA0614
Previous symbols
C12orf51
MANE Select transcript
ENST00000682272.1NM_001388303.1
Locus type
gene with protein product

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads HECTD4 yet. The test sequences your whole genome, so your data includes it all the same.

How HECTD4 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 12, with a bracket where HECTD4 sits. HECTD4 and 11 genes near it on chromosome 12, from 111,771,313 to 112,771,312.Chromosome 1212q24.13p13.33p13.32p13.31p13.2p13.1p12.3p12.2p12.1p11.23p11.22p11.21p11.1q11q12q13.11q13.12q13.13q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.31q24.32q24.33111.8 Mb112 Mb112.2 Mb112.4 Mb112.6 Mb: 111,753,890–111,791,418, forward strandALDH2: 111,766,887–111,817,532, forward strandALDH2MAPKAPK5: 111,841,998–111,902,222, forward strandMAPKAPK5: 111,842,237–111,842,368, forward strandTMEM116: 111,893,714–112,014,271, reverse strandTMEM116ERP29: 112,012,815–112,026,066, forward strandERP29NAA25: 112,026,689–112,109,434, reverse strandNAA25TRAFD1: 112,125,514–112,153,610, forward strandTRAFD1HECTD4: 112,160,195–112,382,431, reverse strandHECTD4RPL6: 112,403,955–112,418,844, reverse strandRPL6PTPN11: 112,418,351–112,509,918, forward strandPTPN11RPH3A: 112,570,380–112,898,881, forward strandRPH3ADiagram of HECTD4: 76 exons on the reverse strand of chromosome 12Exon 61: 1 known disease-causing siteExon 32: 1 known disease-causing siteExon 30: 1 known disease-causing siteExon 26: 1 known disease-causing siteExon 12: 1 known disease-causing siteExon 76: 112,160,195–112,162,523, 2,329 basesExon 75: 112,163,042–112,163,264, 223 basesExon 74: 112,163,542–112,163,737, 196 basesExon 73: 112,164,109–112,164,275, 167 basesExon 72: 112,167,317–112,167,538, 222 basesExon 71: 112,167,814–112,167,917, 104 basesExon 70: 112,169,503–112,169,658, 156 basesExon 69: 112,170,333–112,170,452, 120 basesExon 68: 112,171,117–112,171,263, 147 basesExon 67: 112,172,671–112,172,861, 191 basesExon 66: 112,175,736–112,175,859, 124 basesExon 65: 112,176,596–112,176,702, 107 basesExon 64: 112,178,931–112,179,082, 152 basesExon 63: 112,179,174–112,179,397, 224 basesExon 62: 112,183,059–112,183,266, 208 basesExon 61: 112,184,187–112,185,493, 1,307 basesExon 60: 112,190,786–112,190,965, 180 basesExon 59: 112,192,560–112,192,765, 206 basesExon 58: 112,193,061–112,193,191, 131 basesExon 57: 112,193,469–112,193,674, 206 basesExon 56: 112,194,885–112,195,066, 182 basesExon 55: 112,200,638–112,200,798, 161 basesExon 54: 112,203,636–112,203,772, 137 basesExon 53: 112,204,486–112,204,623, 138 basesExon 52: 112,207,874–112,208,000, 127 basesExon 51: 112,208,494–112,208,630, 137 basesExon 50: 112,210,015–112,210,252, 238 basesExon 49: 112,212,487–112,212,650, 164 basesExon 48: 112,216,292–112,216,371, 80 basesExon 47: 112,216,773–112,216,921, 149 basesExon 46: 112,217,034–112,217,195, 162 basesExon 45: 112,219,386–112,219,489, 104 basesExon 44: 112,226,643–112,226,758, 116 basesExon 43: 112,228,089–112,228,258, 170 basesExon 42: 112,228,647–112,228,811, 165 basesExon 41: 112,229,698–112,229,880, 183 basesExon 40: 112,230,687–112,230,822, 136 basesExon 39: 112,231,513–112,231,715, 203 basesExon 38: 112,233,004–112,233,085, 82 basesExon 37: 112,235,077–112,235,266, 190 basesExon 36: 112,235,504–112,235,784, 281 basesExon 35: 112,236,945–112,237,098, 154 basesExon 34: 112,239,052–112,239,236, 185 basesExon 33: 112,239,881–112,240,027, 147 basesExon 32: 112,243,353–112,243,519, 167 basesExon 31: 112,243,620–112,243,761, 142 basesExon 30: 112,243,874–112,244,009, 136 basesExon 29: 112,246,901–112,247,076, 176 basesExon 28: 112,247,462–112,247,550, 89 basesExon 27: 112,248,067–112,248,171, 105 basesExon 26: 112,248,320–112,248,512, 193 basesExon 25: 112,250,144–112,250,377, 234 basesExon 24: 112,250,971–112,251,134, 164 basesExon 23: 112,252,424–112,252,528, 105 basesExon 22: 112,254,043–112,254,162, 120 basesExon 21: 112,256,320–112,256,518, 199 basesExon 20: 112,258,496–112,258,596, 101 basesExon 19: 112,259,112–112,259,265, 154 basesExon 18: 112,261,305–112,261,429, 125 basesExon 17: 112,264,084–112,264,212, 129 basesExon 16: 112,265,175–112,265,295, 121 basesExon 15: 112,265,878–112,265,983, 106 basesExon 14: 112,266,912–112,266,982, 71 basesExon 13: 112,269,704–112,269,849, 146 basesExon 12: 112,270,227–112,270,459, 233 basesExon 11: 112,273,655–112,273,795, 141 basesExon 10: 112,274,847–112,274,960, 114 basesExon 9: 112,279,228–112,279,386, 159 basesExon 8: 112,283,110–112,283,302, 193 basesExon 7: 112,306,064–112,306,234, 171 basesExon 6: 112,308,753–112,308,891, 139 basesExon 5: 112,309,561–112,309,669, 109 basesExon 4: 112,313,017–112,313,147, 131 basesExon 3: 112,314,457–112,314,546, 90 basesExon 2: 112,319,225–112,319,742, 518 basesExon 1: 112,381,952–112,382,431, 480 bases767060504030201015′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 15.8 kb of the gene's 222.2 kb; 13,257 of those bases code for the protein.

How a genome test reads HECTD4

6

positions in HECTD4 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 222.2 kb of HECTD4, introns included, not only the 15.8 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). HECTD4 gene: HECT domain E3 ubiquitin protein ligase 4. Retrieved 16 October 2026, from https://dantelabs.com/genes/hectd4

Vancouver

Dante Labs. HECTD4 gene: HECT domain E3 ubiquitin protein ligase 4 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/hectd4

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