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Gene

PIGG

phosphatidylinositol glycan anchor biosynthesis class G (EMM blood group)

Summary

Cytogenetic location
4p16.3
Coordinates
Chromosome 4: 499,210–540,200 (GRCh38)
Exons
13 exons across 41 kb
Protein
983 amino acids
Also known as
FLJ20265, GPI7, LAS21
MANE Select transcript
ENST00000453061.7NM_001127178.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • GPI Anchor Biosynthesis Defects

    • Disorders of GPI Anchor Biosynthesis

      A group of inherited conditions caused by variants in the PIG, PGAP and related genes needed to make and attach the GPI anchor, typically causing developmental delay, low muscle tone and epilepsy.

      • 4 GenCC submitters rate it definitive or strong

Broader groupings

  • Congenital Disorders of Glycosylation

    • Congenital Disorders of Glycosylation (CDG)

      One of 98 genes linked to it

      A large group of inherited conditions in which sugar chains (glycans) are not correctly built or attached to proteins and lipids, often affecting the brain, liver, blood clotting, growth and many other body systems. Most are autosomal recessive, but some are X-linked or autosomal dominant.

      • 4 GenCC submitters rate it definitive or strong

  • Intellectual Disability

    • One of 233 genes linked to it

      • 4 GenCC submitters rate it definitive or strong

How PIGG is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 4, with a bracket where PIGG sits. PIGG and 18 genes near it on chromosome 4, from 19,705 to 1,019,704.Chromosome 44p16.3p16.3p16.2p16.1p15.33p15.32p15.31p15.2p15.1p14p13p12p11q11q12q13.1q13.2q13.3q21.1q21.21q21.22q21.23q21.3q22.1q22.2q22.3q23q24q25q26q27q28.1q28.2q28.3q31.1q31.21q31.22q31.23q31.3q32.1q32.2q32.3q33q34.1q34.2q34.3q35.1q35.20.2 Mb0.4 Mb0.6 Mb0.8 Mb1 MbZNF595: 53,283–106,453, forward strandZNF595ZNF718: 124,456–210,714, forward strandZNF718ZNF732: 270,675–305,483, reverse strandZNF732ZNF141: 337,762–384,868, forward strandZNF141ZNF721: 391,179–499,159, reverse strandZNF721PIGG: 499,210–540,200, forward strandPIGGTMEM271: 573,880–576,295, reverse strandTMEM271PDE6B: 625,559–670,782, forward strandPDE6BATP5ME: 672,423–674,400, reverse strandATP5MEMYL5: 673,519–682,033, forward strandMYL5SLC49A3: 681,824–689,548, reverse strandSLC49A3PCGF3: 705,748–770,089, forward strandPCGF3CPLX1: 784,957–827,043, reverse strandCPLX1GAK: 849,275–932,411, reverse strandGAKTMEM175: 932,153–958,989, forward strandTMEM175DGKQ: 958,884–986,895, reverse strandDGKQSLC26A1: 978,992–997,659, reverse strandSLC26A1IDUA: 986,997–1,008,344, forward strandIDUAFGFRL1: 1,008,649–1,026,901, forward strandFGFRL1Diagram of PIGG: 13 exons on the forward strand of chromosome 4Exon 1: 1 known disease-causing siteExon 2: 3 known disease-causing sitesExon 3: 2 known disease-causing sitesExon 4: 3 known disease-causing sitesExon 5: 4 known disease-causing sitesExon 6: 4 known disease-causing sitesExon 7: 5 known disease-causing sitesExon 8: 5 known disease-causing sitesExon 9: 14 known disease-causing sitesExon 10: 3 known disease-causing sitesExon 11: 9 known disease-causing sitesExon 12: 2 known disease-causing sitesExon 13: 3 known disease-causing sitesExon 1: 499,210–499,489, 280 basesExon 2: 500,396–500,601, 206 basesExon 3: 505,718–505,927, 210 basesExon 4: 507,405–507,593, 189 basesExon 5: 508,829–508,970, 142 basesExon 6: 515,973–516,185, 213 basesExon 7: 521,056–521,273, 218 basesExon 8: 521,660–521,941, 282 basesExon 9: 523,459–523,913, 455 basesExon 10: 527,039–527,230, 192 basesExon 11: 530,436–530,745, 310 basesExon 12: 533,818–533,981, 164 basesExon 13: 539,153–540,200, 1,048 bases123456789101112135′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3.9 kb of the gene's 41 kb; 2,952 of those bases code for the protein.

How a genome test reads PIGG

73

positions in PIGG where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 41 kb of PIGG, introns included, not only the 3.9 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). PIGG gene: phosphatidylinositol glycan anchor biosynthesis class G (EMM blood group). Retrieved 16 October 2026, from https://dantelabs.com/genes/pigg

Vancouver

Dante Labs. PIGG gene: phosphatidylinositol glycan anchor biosynthesis class G (EMM blood group) [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/pigg

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