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Gene

PIEZO2

piezo type mechanosensitive ion channel component 2

Summary

Cytogenetic location
18p11.22-p11.21
Coordinates
Chromosome 18: 10,670,247–11,149,569 (GRCh38)
Exons
56 exons across 479.3 kb
Protein
2,865 amino acids
Also known as
FLJ23403, FLJ23144, HsT748, HsT771, FLJ34907
Previous symbols
FAM38B2, C18orf30, C18orf58, FAM38B
MANE Select transcript
ENST00000674853.1NM_001378183.1
Locus type
gene with protein product

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads PIEZO2 yet. The test sequences your whole genome, so your data includes it all the same.

How PIEZO2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 18, with a bracket where PIEZO2 sits. PIEZO2 and 3 genes near it on chromosome 18, from 10,190,924 to 11,628,892.Chromosome 1818p11.22-p11.21p11.32p11.31p11.23p11.22p11.21p11.1q11.1q11.2q12.1q12.2q12.3q21.1q21.2q21.31q21.32q21.33q22.1q22.2q22.3q2310.2 Mb10.4 Mb10.6 Mb10.8 Mb11 Mb11.2 Mb11.4 Mb11.6 MbAPCDD1: 10,454,589–10,489,949, forward strandAPCDD1NAPG: 10,525,905–10,553,249, forward strandNAPGPIEZO2: 10,670,247–11,149,569, reverse strandPIEZO2SLC35G4: 11,609,596–11,610,612, forward strandSLC35G4Diagram of PIEZO2: 56 exons on the reverse strand of chromosome 18Exon 56: 4 known disease-causing sitesExon 52: 3 known disease-causing sitesExon 50: 4 known disease-causing sitesExon 49: 2 known disease-causing sitesExon 47: 3 known disease-causing sitesExon 46: 1 known disease-causing siteExon 44: 1 known disease-causing siteExon 42: 1 known disease-causing siteExon 41: 3 known disease-causing sitesExon 38: 1 known disease-causing siteExon 37: 1 known disease-causing siteExon 34: 2 known disease-causing sitesExon 29: 1 known disease-causing siteExon 25: 2 known disease-causing sitesExon 24: 1 known disease-causing siteExon 22: 2 known disease-causing sitesExon 21: 2 known disease-causing sitesExon 20: 2 known disease-causing sitesExon 17: 2 known disease-causing sitesExon 15: 4 known disease-causing sitesExon 14: 2 known disease-causing sitesExon 13: 4 known disease-causing sitesExon 12: 2 known disease-causing sitesExon 8: 1 known disease-causing siteExon 7: 1 known disease-causing siteExon 5: 2 known disease-causing sitesExon 3: 1 known disease-causing siteExon 2: 1 known disease-causing siteExon 1: 1 known disease-causing siteExon 56: 10,670,247–10,671,779, 1,533 basesExon 55: 10,672,690–10,672,873, 184 basesExon 54: 10,675,209–10,675,288, 80 basesExon 53: 10,677,747–10,677,875, 129 basesExon 52: 10,680,199–10,680,371, 173 basesExon 51: 10,681,661–10,681,753, 93 basesExon 50: 10,682,104–10,682,292, 189 basesExon 49: 10,689,655–10,689,802, 148 basesExon 48: 10,691,225–10,691,383, 159 basesExon 47: 10,696,074–10,696,288, 215 basesExon 46: 10,696,392–10,696,539, 148 basesExon 45: 10,697,748–10,697,880, 133 basesExon 44: 10,698,925–10,699,177, 253 basesExon 43: 10,701,989–10,702,171, 183 basesExon 42: 10,704,394–10,704,652, 259 basesExon 41: 10,705,336–10,705,746, 411 basesExon 40: 10,708,275–10,708,439, 165 basesExon 39: 10,714,764–10,714,930, 167 basesExon 38: 10,715,650–10,715,816, 167 basesExon 37: 10,718,200–10,718,259, 60 basesExon 36: 10,731,407–10,731,521, 115 basesExon 35: 10,735,232–10,735,330, 99 basesExon 34: 10,736,604–10,736,710, 107 basesExon 33: 10,741,031–10,741,102, 72 basesExon 32: 10,742,494–10,742,615, 122 basesExon 31: 10,744,142–10,744,231, 90 basesExon 30: 10,748,471–10,748,630, 160 basesExon 29: 10,750,091–10,750,187, 97 basesExon 28: 10,752,636–10,752,879, 244 basesExon 27: 10,757,969–10,758,134, 166 basesExon 26: 10,759,482–10,759,583, 102 basesExon 25: 10,759,705–10,759,909, 205 basesExon 24: 10,760,911–10,761,111, 201 basesExon 23: 10,762,500–10,762,625, 126 basesExon 22: 10,762,922–10,763,098, 177 basesExon 21: 10,770,148–10,770,308, 161 basesExon 20: 10,773,412–10,773,629, 218 basesExon 19: 10,774,006–10,774,038, 33 basesExon 18: 10,780,325–10,780,366, 42 basesExon 17: 10,784,784–10,784,957, 174 basesExon 16: 10,787,036–10,787,184, 149 basesExon 15: 10,789,079–10,789,365, 287 basesExon 14: 10,791,201–10,791,324, 124 basesExon 13: 10,794,772–10,795,002, 231 basesExon 12: 10,797,374–10,797,522, 149 basesExon 11: 10,800,337–10,800,475, 139 basesExon 10: 10,801,390–10,801,428, 39 basesExon 9: 10,803,875–10,803,994, 120 basesExon 8: 10,807,112–10,807,274, 163 basesExon 7: 10,855,353–10,855,566, 214 basesExon 6: 10,857,001–10,857,211, 211 basesExon 5: 10,871,253–10,871,415, 163 basesExon 4: 10,911,186–10,911,228, 43 basesExon 3: 10,979,535–10,979,660, 126 basesExon 2: 11,066,127–11,066,222, 96 basesExon 1: 11,148,525–11,149,569, 1,045 bases56504030201015′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 10.9 kb of the gene's 479.3 kb; 8,598 of those bases code for the protein.

How a genome test reads PIEZO2

72

positions in PIEZO2 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 479.3 kb of PIEZO2, introns included, not only the 10.9 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). PIEZO2 gene: piezo type mechanosensitive ion channel component 2. Retrieved 17 October 2026, from https://dantelabs.com/genes/piezo2

Vancouver

Dante Labs. PIEZO2 gene: piezo type mechanosensitive ion channel component 2 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/piezo2

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