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Gene

RHOA

ras homolog family member A

Summary

Cytogenetic location
3p21.31
Coordinates
Chromosome 3: 49,359,145–49,411,976 (GRCh38)
Exons
5 exons across 52.8 kb
Protein
193 amino acids
Also known as
Rho12, RHOH12
Previous symbols
ARH12, ARHA
MANE Select transcript
ENST00000418115.6NM_001664.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads RHOA yet. The test sequences your whole genome, so your data includes it all the same.

How RHOA is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 3, with a bracket where RHOA sits. RHOA and 37 genes near it on chromosome 3, from 48,885,561 to 49,885,560.Chromosome 33p21.31p26.3p26.2p26.1p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p14.3p14.2p14.1p13p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13.11q13.12q13.13q13.2q13.31q13.32q13.33q21.1q21.2q21.3q22.1q22.2q22.3q23q24q25.1q25.2q25.31q25.32q25.33q26.1q26.2q26.31q26.32q26.33q27.1q27.2q27.3q28q2949 Mb49.2 Mb49.4 Mb49.6 Mb49.8 MbSLC25A20: 48,856,926–48,898,993, reverse strandSLC25A20ARIH2: 48,918,217–48,986,382, forward strandARIH2P4HTM: 48,989,858–49,007,153, forward strandWDR6: 49,007,062–49,015,953, forward strandDALRD3: 49,015,474–49,022,293, reverse strandNDUFAF3: 49,020,459–49,027,593, forward strandNDUFAF3IMPDH2: 49,024,315–49,029,452, reverse strandIMPDH2: 49,024,345–49,094,071, reverse strandQRICH1: 49,029,700–49,094,545, reverse strandQRICH1QARS1: 49,095,932–49,105,130, reverse strandQARS1USP19: 49,105,758–49,120,940, reverse strandUSP19LAMB2: 49,121,113–49,133,118, reverse strandLAMB2CCDC71: 49,161,063–49,166,357, reverse strandCCDC71KLHDC8B: 49,171,239–49,176,487, forward strandKLHDC8BCIMIP7: 49,177,634–49,191,858, reverse strandCIMIP7IHO1: 49,198,428–49,277,629, forward strandIHO1C3orf62: 49,268,596–49,277,236, reverse strandC3orf62USP4: 49,277,144–49,340,712, reverse strandUSP4GPX1: 49,357,174–49,358,605, reverse strandGPX1: 49,357,176–49,412,051, reverse strandRHOA: 49,359,145–49,411,976, reverse strandRHOATCTA: 49,412,212–49,455,826, forward strandAMT: 49,416,771–49,422,685, reverse strandAMT: 49,416,777–49,429,314, reverse strandNICN1: 49,422,333–49,429,331, reverse strandDAG1: 49,468,649–49,535,624, forward strandDAG1BSN: 49,554,477–49,671,549, forward strandBSNAPEH: 49,673,818–49,683,973, forward strandAPEHMST1: 49,683,922–49,689,501, reverse strandMST1RNF123: 49,688,740–49,723,389, forward strandRNF123AMIGO3: 49,716,829–49,719,684, reverse strandAMIGO3GMPPB: 49,716,844–49,723,988, reverse strandIP6K1: 49,724,294–49,786,557, reverse strandIP6K1CDHR4: 49,790,732–49,799,879, reverse strandCDHR4INKA1: 49,803,228–49,805,237, forward strandINKA1UBA7: 49,805,205–49,814,151, reverse strandUBA7TRAIP: 49,828,595–49,856,597, reverse strandTRAIPCAMKV: 49,857,214–49,870,064, reverse strandCAMKVDiagram of RHOA: 5 exons on the reverse strand of chromosome 3Exon 3: 1 known disease-causing siteExon 2: 1 known disease-causing siteExon 5: 49,359,145–49,360,382, 1,238 basesExon 4: 49,362,496–49,362,626, 131 basesExon 3: 49,368,428–49,368,548, 121 basesExon 2: 49,375,434–49,375,591, 158 basesExon 1: 49,411,820–49,411,976, 157 bases543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.8 kb of the gene's 52.8 kb; 582 of those bases code for the protein.

How a genome test reads RHOA

2

positions in RHOA where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 52.8 kb of RHOA, introns included, not only the 1.8 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). RHOA gene: ras homolog family member A. Retrieved 16 October 2026, from https://dantelabs.com/genes/rhoa

Vancouver

Dante Labs. RHOA gene: ras homolog family member A [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/rhoa

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