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Gene

RPS26

ribosomal protein S26

Summary

Cytogenetic location
12q13.2
Coordinates
Chromosome 12: 56,041,918–56,044,697 (GRCh38)
Exons
4 exons across 2.8 kb
Protein
115 amino acids
Inheritance
Autosomal dominant
Also known as
S26, eS26
MANE Select transcript
ENST00000646449.2NM_001029.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Diamond-Blackfan Anemia

    • Autosomal dominant

      A congenital aregenerative and often macrocytic anemia with erythroblastopenia.

      • 3 GenCC submitters rate it definitive or strong

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

How RPS26 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 12, with a bracket where RPS26 sits. RPS26 and 49 genes near it on chromosome 12, from 55,543,308 to 56,543,307.Chromosome 1212q13.2p13.33p13.32p13.31p13.2p13.1p12.3p12.2p12.1p11.23p11.22p11.21p11.1q11q12q13.11q13.12q13.13q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.31q24.32q24.3355.6 Mb55.8 Mb56 Mb56.2 Mb56.4 MbOR6C4: 55,549,602–55,555,832, forward strandOR6C4OR2AP1: 55,572,468–55,575,612, forward strandOR2AP1OR10P1: 55,636,892–55,637,833, forward strandOR10P1ITGA7: 55,679,139–55,716,404, reverse strandTMT1B: 55,681,445–55,695,748, forward strandBLOC1S1: 55,715,911–55,720,087, forward strand: 55,716,036–55,724,703, forward strandRDH5: 55,720,367–55,724,714, forward strandRDH5CD63: 55,723,511–55,737,367, reverse strandCD63GDF11: 55,743,122–55,757,264, forward strandGDF11SARNP: 55,751,195–55,817,912, reverse strand: 55,757,275–55,827,546, reverse strandORMDL2: 55,818,034–55,824,097, forward strandORMDL2DNAJC14: 55,818,839–55,830,824, reverse strandDNAJC14MMP19: 55,835,433–55,843,005, reverse strandMMP19PYM1: 55,901,413–55,932,618, reverse strandPYM1DGKA: 55,927,319–55,954,027, forward strandDGKAPMEL: 55,954,104–55,973,317, reverse strandPMELCDK2: 55,966,781–55,972,789, forward strandCDK2RAB5B: 55,973,859–55,996,683, forward strandRAB5BSUOX: 55,996,855–56,006,641, forward strandSUOXIKZF4: 56,007,392–56,038,435, forward strandIKZF4RPS26: 56,041,918–56,044,697, forward strandRPS26ERBB3: 56,076,799–56,103,505, forward strandERBB3: 56,101,331–56,109,289, forward strandPA2G4: 56,104,349–56,116,329, forward strandPA2G4RPL41: 56,116,585–56,117,967, forward strandRPL41ZC3H10: 56,118,243–56,127,514, forward strandESYT1: 56,118,250–56,150,107, forward strandMYL6B: 56,151,966–56,159,647, forward strandMYL6: 56,158,322–56,166,572, forward strandMYL6SMARCC2: 56,162,359–56,189,587, reverse strandRNF41: 56,202,179–56,224,275, reverse strandRNF41NABP2: 56,221,978–56,229,860, forward strandNABP2SLC39A5: 56,230,039–56,238,214, forward strandSLC39A5ANKRD52: 56,237,807–56,258,665, reverse strandANKRD52COQ10A: 56,266,846–56,271,736, forward strandCS: 56,271,699–56,300,395, reverse strandCS: 56,285,916–56,316,059, reverse strandCNPY2: 56,308,024–56,316,363, reverse strandCNPY2PAN2: 56,316,223–56,334,053, reverse strandPAN2IL23A: 56,334,174–56,340,410, forward strandIL23ASTAT2: 56,338,356–56,360,283, reverse strandSTAT2APOF: 56,360,565–56,362,862, reverse strandAPOFTIMELESS: 56,416,363–56,449,457, reverse strandTIMELESSMIP: 56,449,502–56,469,166, reverse strandMIP: 56,449,700–56,488,170, reverse strandSPRYD4: 56,468,537–56,479,708, forward strandSPRYD4GLS2: 56,470,945–56,488,414, reverse strandRBMS2: 56,521,807–56,617,037, forward strandRBMS2Diagram of RPS26: 4 exons on the forward strand of chromosome 12Exon 1: 2 known disease-causing sitesExon 2: 9 known disease-causing sitesExon 3: 4 known disease-causing sitesExon 1: 56,041,918–56,042,169, 252 basesExon 2: 56,042,425–56,042,602, 178 basesExon 3: 56,043,363–56,043,493, 131 basesExon 4: 56,044,119–56,044,697, 579 bases12345′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.1 kb of the gene's 2.8 kb; 348 of those bases code for the protein.

How a genome test reads RPS26

23

positions in RPS26 where ClinVar classes a change as pathogenic or likely pathogenic

12 of them (52%) fall in regions short reads find hard.

  • Low mappability (12 sites)Regions where 100 bp or 250 bp reads cannot be placed uniquely.

A whole genome covers all 2.8 kb of RPS26, introns included, not only the 1.1 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). RPS26 gene: ribosomal protein S26. Retrieved 16 October 2026, from https://dantelabs.com/genes/rps26

Vancouver

Dante Labs. RPS26 gene: ribosomal protein S26 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/rps26

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