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Gene

FLI1

Fli-1 proto-oncogene, ETS transcription factor

Summary

Cytogenetic location
11q24.3
Coordinates
Chromosome 11: 128,694,072–128,813,267 (GRCh38)
Exons
9 exons across 119.2 kb
Protein
452 amino acids
Also known as
SIC-1, EWSR2, FLI-1
MANE Select transcript
ENST00000527786.7NM_002017.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Inherited Thrombocytopenias

    • Inherited Thrombocytopenia

      A group of conditions causing a lifelong low platelet count, linked to genes such as MYH9, ANKRD26, ETV6, WAS, MPL, RBM8A, GATA1 and MECOM, and inherited in dominant, recessive or X-linked patterns.

      • ClinGen rates the link moderate
      • 2 GenCC submitters rate it definitive or strong
      What knowing changes

      A genetic diagnosis avoids misdiagnosis as immune thrombocytopenia, with unnecessary steroids or spleen removal, and guides monitoring for related kidney, hearing or blood problems.

How FLI1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 11, with a bracket where FLI1 sits. FLI1 and 5 genes near it on chromosome 11, from 128,253,670 to 129,253,669.Chromosome 1111q24.3p15.5p15.4p15.3p15.2p15.1p14.3p14.2p14.1p13p12p11.2p11.12p11.11q11q12.1q12.2q12.3q13.1q13.2q13.3q13.4q13.5q14.1q14.2q14.3q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q25128.4 Mb128.6 Mb128.8 Mb129 Mb129.2 MbETS1: 128,458,761–128,587,611, reverse strandETS1FLI1: 128,694,072–128,813,267, forward strandFLI1KCNJ1: 128,836,315–128,874,671, reverse strandKCNJ1KCNJ5: 128,890,453–128,922,733, forward strandKCNJ5TP53AIP1: 128,934,731–128,943,399, reverse strandTP53AIP1ARHGAP32: 128,965,060–129,279,324, reverse strandARHGAP32Diagram of FLI1: 9 exons on the forward strand of chromosome 11Exon 9: 3 known disease-causing sitesExon 1: 128,694,072–128,694,276, 205 basesExon 2: 128,758,115–128,758,326, 212 basesExon 3: 128,768,118–128,768,272, 155 basesExon 4: 128,772,782–128,772,985, 204 basesExon 5: 128,781,958–128,782,023, 66 basesExon 6: 128,805,366–128,805,431, 66 basesExon 7: 128,807,180–128,807,239, 60 basesExon 8: 128,809,157–128,809,204, 48 basesExon 9: 128,810,459–128,813,267, 2,809 bases1246895′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3.8 kb of the gene's 119.2 kb; 1,359 of those bases code for the protein.

How a genome test reads FLI1

3

positions in FLI1 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 119.2 kb of FLI1, introns included, not only the 3.8 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). FLI1 gene: Fli-1 proto-oncogene, ETS transcription factor. Retrieved 16 October 2026, from https://dantelabs.com/genes/fli1

Vancouver

Dante Labs. FLI1 gene: Fli-1 proto-oncogene, ETS transcription factor [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/fli1

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