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Gene

PIGW

phosphatidylinositol glycan anchor biosynthesis class W

Summary

Cytogenetic location
17q12
Coordinates
Chromosome 17: 36,534,987–36,539,303 (GRCh38)
Exons
2 exons across 4.3 kb
Protein
504 amino acids
Inheritance
Autosomal recessive
Also known as
Gwt1, FLJ37433, PIG-W
MANE Select transcript
ENST00000614443.2NM_001346754.2
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • GPI Anchor Biosynthesis Defects

    • Hyperphosphatasia With Impaired Intellectual Development (Mabry Syndrome)Autosomal recessive

      A group of GPI anchor defects (PIGV, PIGO, PGAP2, PGAP3, PIGW, PIGY) in which a persistently high alkaline phosphatase accompanies developmental delay, seizures and short end bones of the fingers.

      • 2 GenCC submitters rate it definitive or strong
      What knowing changes

      Some affected children have had seizure control improved with pyridoxine (vitamin B6), so a diagnosis can guide a specialist trial of treatment.

    • Disorders of GPI Anchor Biosynthesis

      A group of inherited conditions caused by variants in the PIG, PGAP and related genes needed to make and attach the GPI anchor, typically causing developmental delay, low muscle tone and epilepsy.

      • 2 GenCC submitters rate it definitive or strong

Broader groupings

  • Congenital Disorders of Glycosylation

    • Congenital Disorders of Glycosylation (CDG)

      One of 98 genes linked to it

      A large group of inherited conditions in which sugar chains (glycans) are not correctly built or attached to proteins and lipids, often affecting the brain, liver, blood clotting, growth and many other body systems. Most are autosomal recessive, but some are X-linked or autosomal dominant.

      • 2 GenCC submitters rate it definitive or strong

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How PIGW is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 17, with a bracket where PIGW sits. PIGW and 17 genes near it on chromosome 17, from 36,037,145 to 37,037,144.Chromosome 1717q12p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.336.2 Mb36.4 Mb36.6 Mb36.8 Mb37 MbCCL18: 36,064,228–36,072,032, forward strandCCL18CCL3: 36,088,256–36,090,169, reverse strandCCL3CCL4: 36,103,588–36,105,627, forward strandCCL4TBC1D3B: 36,165,683–36,176,636, reverse strandTBC1D3BCCL3L3: 36,194,869–36,196,758, reverse strandCCL3L3CCL4L2: 36,210,924–36,212,878, forward strandCCL4L2TBC1D3I: 36,253,456–36,264,570, reverse strandTBC1D3ITBC1D3G: 36,323,884–36,334,759, forward strandTBC1D3GTBC1D3H: 36,377,531–36,388,435, reverse strandTBC1D3HTBC1D3F: 36,428,612–36,439,566, reverse strandTBC1D3FZNHIT3: 36,486,629–36,499,310, forward strandZNHIT3MYO19: 36,495,118–36,545,889, reverse strandMYO19PIGW: 36,534,987–36,539,303, forward strandPIGWGGNBP2: 36,544,888–36,589,866, forward strandGGNBP2DHRS11: 36,591,782–36,600,809, forward strandDHRS11MRM1: 36,601,571–36,621,636, forward strandMRM1LHX1: 36,936,784–36,944,612, forward strandLHX1AATF: 36,948,925–37,056,874, forward strandAATFDiagram of PIGW: 2 exons on the forward strand of chromosome 17Exon 2: 1 known disease-causing siteExon 1: 36,534,987–36,535,592, 606 basesExon 2: 36,537,094–36,539,303, 2,210 bases125′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.8 kb of the gene's 4.3 kb; 1,515 of those bases code for the protein.

How a genome test reads PIGW

1

position in PIGW where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 4.3 kb of PIGW, introns included, not only the 2.8 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). PIGW gene: phosphatidylinositol glycan anchor biosynthesis class W. Retrieved 16 October 2026, from https://dantelabs.com/genes/pigw

Vancouver

Dante Labs. PIGW gene: phosphatidylinositol glycan anchor biosynthesis class W [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/pigw

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