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Gene

RAD21

RAD21 cohesin complex component

Summary

Cytogenetic location
8q24.11
Coordinates
Chromosome 8: 116,845,934–116,874,776 (GRCh38)
Exons
14 exons across 28.8 kb
Protein
631 amino acids
Also known as
KIAA0078, hHR21, SCC1
MANE Select transcript
ENST00000297338.7NM_006265.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Cornelia de Lange Syndrome

    • A developmental disorder caused by variants in NIPBL, SMC1A, SMC3, RAD21, HDAC8 or BRD4, with a wide range of severity.

      • ClinGen rates the link definitive
      • 4 GenCC submitters rate it definitive or strong
      What knowing changes

      Diagnosis guides monitoring for associated problems such as reflux, heart defects, hearing and vision issues.

How RAD21 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 8, with a bracket where RAD21 sits. RAD21 and 4 genes near it on chromosome 8, from 116,360,355 to 117,360,354.Chromosome 88q24.11p23.3p23.2p23.1p22p21.3p21.2p21.1p12p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q12.1q12.2q12.3q13.1q13.2q13.3q21.11q21.12q21.13q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.3116.4 Mb116.6 Mb116.8 Mb117 Mb117.2 MbEIF3H: 116,642,130–116,766,925, reverse strandEIF3HUTP23: 116,766,492–116,850,585, forward strandUTP23RAD21: 116,845,934–116,874,776, reverse strandRAD21AARD: 116,938,184–116,948,737, forward strandAARDSLC30A8: 116,950,273–117,176,714, forward strandSLC30A8Diagram of RAD21: 14 exons on the reverse strand of chromosome 8Exon 14: 5 known disease-causing sitesExon 13: 1 known disease-causing siteExon 12: 1 known disease-causing siteExon 11: 1 known disease-causing siteExon 10: 2 known disease-causing sitesExon 9: 2 known disease-causing sitesExon 8: 2 known disease-causing sitesExon 6: 7 known disease-causing sitesExon 5: 3 known disease-causing sitesExon 4: 1 known disease-causing siteExon 3: 4 known disease-causing sitesExon 2: 4 known disease-causing sitesExon 14: 116,845,934–116,847,691, 1,758 basesExon 13: 116,848,946–116,849,029, 84 basesExon 12: 116,850,618–116,850,767, 150 basesExon 11: 116,851,948–116,852,096, 149 basesExon 10: 116,852,549–116,852,708, 160 basesExon 9: 116,854,245–116,854,468, 224 basesExon 8: 116,856,166–116,856,288, 123 basesExon 7: 116,856,646–116,856,771, 126 basesExon 6: 116,857,267–116,857,473, 207 basesExon 5: 116,858,352–116,858,458, 107 basesExon 4: 116,861,841–116,861,940, 100 basesExon 3: 116,863,130–116,863,259, 130 basesExon 2: 116,866,586–116,866,761, 176 basesExon 1: 116,874,611–116,874,776, 166 bases141210864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3.7 kb of the gene's 28.8 kb; 1,896 of those bases code for the protein.

How a genome test reads RAD21

37

positions in RAD21 where ClinVar classes a change as pathogenic or likely pathogenic

5 of them (14%) fall in regions short reads find hard.

  • Segmental duplications (5 sites)Copies of at least 1 kb sharing at least 90% identity with another part of the genome (paralogues, pseudogenes); reads may align to the wrong copy.

A whole genome covers all 28.8 kb of RAD21, introns included, not only the 3.7 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). RAD21 gene: RAD21 cohesin complex component. Retrieved 17 October 2026, from https://dantelabs.com/genes/rad21

Vancouver

Dante Labs. RAD21 gene: RAD21 cohesin complex component [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/rad21

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