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Gene

IGF1R

insulin like growth factor 1 receptor

Summary

Cytogenetic location
15q26.3
Coordinates
Chromosome 15: 98,648,539–98,964,530 (GRCh38)
Exons
21 exons across 316 kb
Protein
1,367 amino acids
Also known as
JTK13, CD221, IGFIR, MGC18216, IGFR
MANE Select transcript
ENST00000650285.1NM_000875.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Growth Hormone Insensitivity & IGF-1 Axis Disorders

    • Growth hormone insensitivity syndrome

      Short stature with normal or high growth hormone but low IGF-1, including Laron syndrome (GHR), IGF1, IGFALS and IGF1R defects, and STAT5B deficiency with immune dysregulation.

      • 3 GenCC submitters rate it definitive or strong
      What knowing changes

      Recombinant IGF-1 (mecasermin) can improve growth in some forms; STAT5B deficiency also needs immune and lung follow-up.

How IGF1R is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 15, with a bracket where IGF1R sits. IGF1R and 4 genes near it on chromosome 15, from 98,306,535 to 99,306,534.Chromosome 1515q26.3p13p12p11.2p11.1q11.1q11.2q12q13.1q13.2q13.3q14q15.1q15.2q15.3q21.1q21.2q21.3q22.1q22.2q22.31q22.32q22.33q23q24.1q24.2q24.3q25.1q25.2q25.3q26.1q26.2q26.398.4 Mb98.6 Mb98.8 Mb99 Mb99.2 MbIGF1R: 98,648,539–98,964,530, forward strandIGF1RPGPEP1L: 98,966,720–99,007,792, reverse strandPGPEP1LSYNM: 99,098,217–99,135,848, forward strandSYNMTTC23: 99,136,323–99,251,232, reverse strandTTC23LRRC28: 99,250,937–99,390,729, forward strandLRRC28Diagram of IGF1R: 21 exons on the forward strand of chromosome 15Exon 1: 1 known disease-causing siteExon 2: 6 known disease-causing sitesExon 3: 2 known disease-causing sitesExon 4: 3 known disease-causing sitesExon 5: 1 known disease-causing siteExon 6: 1 known disease-causing siteExon 7: 1 known disease-causing siteExon 9: 1 known disease-causing siteExon 10: 1 known disease-causing siteExon 11: 4 known disease-causing sitesExon 12: 1 known disease-causing siteExon 13: 1 known disease-causing siteExon 16: 2 known disease-causing sitesExon 18: 4 known disease-causing sitesExon 19: 4 known disease-causing sitesExon 20: 2 known disease-causing sitesExon 1: 98,648,539–98,649,675, 1,137 basesExon 2: 98,707,562–98,708,107, 546 basesExon 3: 98,891,325–98,891,637, 313 basesExon 4: 98,896,757–98,896,905, 149 basesExon 5: 98,899,477–98,899,621, 145 basesExon 6: 98,908,685–98,908,899, 215 basesExon 7: 98,911,315–98,911,441, 127 basesExon 8: 98,913,044–98,913,282, 239 basesExon 9: 98,915,964–98,916,131, 168 basesExon 10: 98,916,672–98,916,876, 205 basesExon 11: 98,922,148–98,922,431, 284 basesExon 12: 98,923,876–98,924,012, 137 basesExon 13: 98,924,525–98,924,684, 160 basesExon 14: 98,929,558–98,929,660, 103 basesExon 15: 98,930,235–98,930,305, 71 basesExon 16: 98,934,824–98,935,053, 230 basesExon 17: 98,935,316–98,935,426, 111 basesExon 18: 98,939,201–98,939,360, 160 basesExon 19: 98,942,923–98,943,052, 130 basesExon 20: 98,948,574–98,948,708, 135 basesExon 21: 98,957,061–98,964,530, 7,470 bases15101520215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 12.2 kb of the gene's 316 kb; 4,104 of those bases code for the protein.

How a genome test reads IGF1R

38

positions in IGF1R where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 316 kb of IGF1R, introns included, not only the 12.2 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). IGF1R gene: insulin like growth factor 1 receptor. Retrieved 17 October 2026, from https://dantelabs.com/genes/igf1r

Vancouver

Dante Labs. IGF1R gene: insulin like growth factor 1 receptor [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/igf1r

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