Skip to content
Use your HSA or FSA funds

Gene

GPC4

glypican 4

Summary

Cytogenetic location
Xq26.2
Coordinates
Chromosome X: 133,300,103–133,415,489 (GRCh38)
Exons
9 exons across 115.4 kb
Protein
556 amino acids
Also known as
K-glypican
MANE Select transcript
ENST00000370828.4NM_001448.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads GPC4 yet. The test sequences your whole genome, so your data includes it all the same.

How GPC4 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome X, with a bracket where GPC4 sits. GPC4 and 4 genes near it on chromosome X, from 132,857,796 to 133,857,795.Chromosome XXq26.2p22.33p22.32p22.31p22.2p22.13p22.12p22.11p21.3p21.2p21.1p11.4p11.3p11.23p11.22p11.21p11.1q11.1q11.2q12q13.1q13.2q13.3q21.1q21.2q21.31q21.32q21.33q22.1q22.2q22.3q23q24q25q26.1q26.2q26.3q27.1q27.2q27.3q28133 Mb133.2 Mb133.4 Mb133.6 Mb133.8 MbHS6ST2: 132,626,015–132,961,395, reverse strandHS6ST2USP26: 133,023,168–133,097,109, reverse strandUSP26TFDP3: 133,216,662–133,218,354, reverse strandTFDP3GPC4: 133,300,103–133,415,489, reverse strandGPC4GPC3: 133,535,745–133,987,100, reverse strandGPC3Diagram of GPC4: 9 exons on the reverse strand of chromosome XExon 9: 4 known disease-causing sitesExon 9: 133,300,103–133,303,069, 2,967 basesExon 8: 133,303,166–133,303,341, 176 basesExon 7: 133,304,725–133,304,861, 137 basesExon 6: 133,305,772–133,305,918, 147 basesExon 5: 133,306,024–133,306,154, 131 basesExon 4: 133,311,258–133,311,423, 166 basesExon 3: 133,324,145–133,324,536, 392 basesExon 2: 133,339,183–133,339,341, 159 basesExon 1: 133,414,806–133,415,489, 684 bases9515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 5 kb of the gene's 115.4 kb; 1,671 of those bases code for the protein.

How a genome test reads GPC4

4

positions in GPC4 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 115.4 kb of GPC4, introns included, not only the 5 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). GPC4 gene: glypican 4. Retrieved 16 October 2026, from https://dantelabs.com/genes/gpc4

Vancouver

Dante Labs. GPC4 gene: glypican 4 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/gpc4

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test