Skip to content
Use your HSA or FSA funds

Gene

KREMEN1

kringle containing transmembrane protein 1

Summary

Cytogenetic location
22q12.1
Coordinates
Chromosome 22: 29,073,035–29,146,820 (GRCh38)
Exons
9 exons across 73.8 kb
Protein
458 amino acids
Inheritance
Autosomal recessive
Also known as
KRM1
Previous symbols
KREMEN
MANE Select transcript
ENST00000400335.9NM_001039570.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Ectodermal Dysplasias

    • Ectodermal dysplasia 13, hair/tooth typeAutosomal recessive

      A KREMEN1 disorder with sparse hair and missing teeth.

      • 1 GenCC submitter rates it definitive or strong

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How KREMEN1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 22, with a bracket where KREMEN1 sits. KREMEN1 and 18 genes near it on chromosome 22, from 28,609,928 to 29,609,927.Chromosome 2222q12.1p13p12p11.2p11.1q11.1q11.21q11.22q11.23q12.1q12.2q12.3q13.1q13.2q13.31q13.32q13.3328.8 Mb29 Mb29.2 Mb29.4 Mb29.6 MbTTC28: 27,978,014–28,679,925, reverse strandTTC28CHEK2: 28,687,738–28,742,422, reverse strandCHEK2HSCB: 28,742,012–28,757,525, forward strandHSCBCCDC117: 28,772,674–28,789,301, forward strandCCDC117XBP1: 28,793,534–28,800,597, reverse strandXBP1ZNRF3: 28,883,537–29,057,488, forward strandZNRF3C22orf31: 29,058,672–29,061,831, reverse strandC22orf31KREMEN1: 29,073,035–29,146,820, forward strandKREMEN1EMID1: 29,205,809–29,259,598, forward strandEMID1RHBDD3: 29,259,850–29,268,221, reverse strandRHBDD3EWSR1: 29,268,009–29,300,530, forward strandEWSR1GAS2L1: 29,306,394–29,312,787, forward strandGAS2L1RASL10A: 29,312,933–29,319,679, reverse strandRASL10AAP1B1: 29,327,680–29,388,612, reverse strandAP1B1RFPL1: 29,438,583–29,442,455, forward strandRFPL1NEFH: 29,480,209–29,491,390, forward strandNEFHTHOC5: 29,505,879–29,555,216, reverse strandTHOC5NIPSNAP1: 29,554,806–29,581,327, reverse strandNIPSNAP1NF2: 29,603,520–29,698,598, forward strandNF2Diagram of KREMEN1: 9 exons on the forward strand of chromosome 22Exon 1: 29,073,035–29,073,227, 193 basesExon 2: 29,094,258–29,094,420, 163 basesExon 3: 29,098,862–29,098,953, 92 basesExon 4: 29,121,357–29,121,481, 125 basesExon 5: 29,125,263–29,125,416, 154 basesExon 6: 29,137,342–29,137,674, 333 basesExon 7: 29,138,624–29,138,782, 159 basesExon 8: 29,140,282–29,140,366, 85 basesExon 9: 29,141,944–29,146,820, 4,877 bases1234567895′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 6.2 kb of the gene's 73.8 kb; 1,377 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). KREMEN1 gene: kringle containing transmembrane protein 1. Retrieved 17 October 2026, from https://dantelabs.com/genes/kremen1

Vancouver

Dante Labs. KREMEN1 gene: kringle containing transmembrane protein 1 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/kremen1

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test