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Gene

RNU2-2

RNA, U2 small nuclear 2

Summary

Cytogenetic location
11q12.3
Coordinates
Chromosome 11: 62,841,619–62,841,809 (GRCh38)
Exons
1 exon across 0.2 kb
Also known as
U2
Previous symbols
RNU2B, RNU2-2P
MANE Select transcript
ENST00000410396.1NR_199791.1
Locus type
RNA, small nuclear

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    • Epilepsy (Full Panel)

      • Epilepsy

        One of 171 genes linked to it

        A brain disorder characterized by episodes of abnormally increased neuronal discharge resulting in transient episodes of sensory or motor neurological dysfunction, or psychic dysfunction. These episodes may or may not be associated with loss of consciousness or convulsions.

        • ClinGen rates the link strong
        • 1 GenCC submitter rates it definitive or strong

    How RNU2-2 is laid out

    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    • Stretches short reads find hard
    Chromosome 11, with a bracket where RNU2-2 sits. RNU2-2 and 41 genes near it on chromosome 11, from 62,341,714 to 63,341,713.Chromosome 1111q12.3p15.5p15.4p15.3p15.2p15.1p14.3p14.2p14.1p13p12p11.2p11.12p11.11q11q12.1q12.2q12.3q13.1q13.2q13.3q13.4q13.5q14.1q14.2q14.3q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q2562.4 Mb62.6 Mb62.8 Mb63 Mb63.2 MbASRGL1: 62,337,347–62,393,415, forward strandASRGL1SCGB1A1: 62,405,103–62,423,195, forward strandSCGB1A1AHNAK: 62,433,532–62,556,235, reverse strandAHNAKEEF1G: 62,559,593–62,574,086, reverse strand: 62,559,603–62,591,531, reverse strandTUT1: 62,575,045–62,591,637, reverse strandMTA2: 62,593,214–62,601,927, reverse strandMTA2EML3: 62,602,216–62,612,978, reverse strandEML3ROM1: 62,611,722–62,615,116, forward strandROM1B3GAT3: 62,614,993–62,622,180, reverse strandB3GAT3GANAB: 62,624,821–62,646,726, reverse strandINTS5: 62,646,848–62,653,316, reverse strand: 62,649,694–62,665,178, reverse strandC11orf98: 62,662,815–62,665,251, reverse strandLBHD1: 62,662,817–62,672,284, reverse strandCSKMT: 62,665,309–62,668,496, forward strandUQCC3: 62,670,273–62,674,001, forward strandUBXN1: 62,676,498–62,679,332, reverse strandUBXN1LRRN4CL: 62,686,406–62,689,609, reverse strandBSCL2: 62,689,289–62,709,861, reverse strandHNRNPUL2-BSCL2: 62,690,275–62,727,384, reverse strandGNG3: 62,706,400–62,712,083, forward strandHNRNPUL2: 62,712,630–62,727,637, reverse strand: 62,726,885–62,727,265, reverse strandTTC9C: 62,727,687–62,740,293, forward strandTTC9CZBTB3: 62,737,172–62,758,835, reverse strandZBTB3POLR2G: 62,761,453–62,766,715, forward strandPOLR2GTAF6L: 62,771,307–62,787,342, forward strandTAF6LTMEM223: 62,771,629–62,792,022, reverse strandTMEM179B: 62,787,375–62,792,166, forward strandNXF1: 62,792,123–62,806,302, reverse strandSTX5: 62,806,860–62,832,076, reverse strandSTX5TEX54: 62,832,321–62,832,841, reverse strandTEX54WDR74: 62,832,342–62,842,228, reverse strandWDR74RNU2-2: 62,841,619–62,841,809, reverse strandRNU2-2SLC3A2: 62,855,970–62,888,910, forward strandSLC3A2CHRM1: 62,907,828–62,921,877, reverse strandCHRM1SLC22A6: 62,936,385–62,984,973, reverse strandSLC22A6SLC22A8: 62,989,154–63,017,561, reverse strandSLC22A8SLC22A24: 63,077,406–63,144,221, reverse strandSLC22A24SLC22A25: 63,158,437–63,243,788, reverse strandSLC22A25SLC22A10: 63,268,022–63,311,874, forward strandSLC22A10Diagram of RNU2-2: one exon on the reverse strand of chromosome 11Exon 1: 3 known disease-causing sitesExon 1: 62,841,619–62,841,809, 191 bases15′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 0.2 kb of the gene's 0.2 kb.

    How a genome test reads RNU2-2

    3

    positions in RNU2-2 where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    A whole genome covers all 0.2 kb of RNU2-2, introns included, not only the 0.2 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). RNU2-2 gene: RNA, U2 small nuclear 2. Retrieved 17 October 2026, from https://dantelabs.com/genes/rnu2-2

    Vancouver

    Dante Labs. RNU2-2 gene: RNA, U2 small nuclear 2 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/rnu2-2

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