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Gene

NECTIN1

nectin cell adhesion molecule 1

Summary

Cytogenetic location
11q23.3
Coordinates
Chromosome 11: 119,660,992–119,729,200 (GRCh38)
Exons
6 exons across 68.2 kb
Protein
517 amino acids
Inheritance
Autosomal recessive
Also known as
PRR, PRR1, PVRR1, SK-12, HIgR, CLPED1, CD111, OFC7, Nectin-1
Previous symbols
HVEC, ED4, PVRL1
MANE Select transcript
ENST00000264025.8NM_002855.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Ectodermal Dysplasias

    • Cleft lip/palate-ectodermal dysplasia syndromeAutosomal recessive

      A NECTIN1 disorder combining cleft lip or palate with hair, tooth and nail anomalies.

      • ClinGen rates the link definitive
      • 3 GenCC submitters rate it definitive or strong

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How NECTIN1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 11, with a bracket where NECTIN1 sits. NECTIN1 and 9 genes near it on chromosome 11, from 119,195,096 to 120,195,095.Chromosome 1111q23.3p15.5p15.4p15.3p15.2p15.1p14.3p14.2p14.1p13p12p11.2p11.12p11.11q11q12.1q12.2q12.3q13.1q13.2q13.3q13.4q13.5q14.1q14.2q14.3q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q25119.2 Mb119.4 Mb119.6 Mb119.8 Mb120 MbDRC12: 119,190,055–119,206,266, reverse strandDRC12CBL: 119,206,036–119,313,926, forward strandCBLMCAM: 119,307,972–119,321,521, reverse strandMCAMRNF26: 119,334,527–119,337,309, forward strandRNF26MFRP: 119,338,942–119,346,705, reverse strandMFRPC1QTNF5: 119,338,942–119,340,940, reverse strandC1QTNF5USP2: 119,355,215–119,381,720, reverse strandUSP2THY1: 119,415,476–119,424,985, reverse strandTHY1NECTIN1: 119,660,992–119,729,200, reverse strandNECTIN1TRIM29: 120,111,286–120,185,529, reverse strandTRIM29Diagram of NECTIN1: 6 exons on the reverse strand of chromosome 11Exon 6: 1 known disease-causing siteExon 3: 1 known disease-causing siteExon 2: 1 known disease-causing siteExon 6: 119,660,992–119,665,297, 4,306 basesExon 5: 119,675,159–119,675,310, 152 basesExon 4: 119,677,102–119,677,219, 118 basesExon 3: 119,677,555–119,677,857, 303 basesExon 2: 119,678,415–119,678,765, 351 basesExon 1: 119,728,475–119,729,200, 726 bases64215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 6 kb of the gene's 68.2 kb; 1,554 of those bases code for the protein.

How a genome test reads NECTIN1

3

positions in NECTIN1 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 68.2 kb of NECTIN1, introns included, not only the 6 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). NECTIN1 gene: nectin cell adhesion molecule 1. Retrieved 17 October 2026, from https://dantelabs.com/genes/nectin1

Vancouver

Dante Labs. NECTIN1 gene: nectin cell adhesion molecule 1 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/nectin1

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