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Gene

TOE1

target of EGR1, exonuclease

Summary

Cytogenetic location
1p34.1
Coordinates
Chromosome 1: 45,340,170–45,343,973 (GRCh38)
Exons
8 exons across 3.8 kb
Protein
510 amino acids
Also known as
hCaf1z, TOE-1
MANE Select transcript
ENST00000372090.6NM_025077.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads TOE1 yet. The test sequences your whole genome, so your data includes it all the same.

How TOE1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 1, with a bracket where TOE1 sits. TOE1 and 19 genes near it on chromosome 1, from 44,842,072 to 45,842,071.Chromosome 11p34.1p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q4445 Mb45.2 Mb45.4 Mb45.6 Mb45.8 MbPTCH2: 44,819,154–44,843,253, reverse strandPTCH2EIF2B3: 44,850,464–44,986,722, reverse strandEIF2B3HECTD3: 45,002,540–45,011,369, reverse strandHECTD3UROD: 45,010,950–45,015,577, forward strandURODZSWIM5: 45,016,395–45,306,209, reverse strandZSWIM5HPDL: 45,326,895–45,328,710, forward strandHPDLMUTYH: 45,329,163–45,340,893, reverse strandMUTYH: 45,329,262–45,491,155, reverse strandTOE1: 45,340,170–45,343,973, forward strandTOE1TESK2: 45,343,877–45,491,203, reverse strandCCDC163: 45,493,863–45,500,163, reverse strandCCDC163MMACHC: 45,500,186–45,513,382, forward strandMMACHCPRDX1: 45,510,914–45,542,816, reverse strandPRDX1AKR1A1: 45,550,475–45,570,051, forward strandAKR1A1NASP: 45,583,576–45,618,905, forward strandNASPCCDC17: 45,620,044–45,624,062, reverse strandCCDC17GPBP1L1: 45,627,284–45,688,408, reverse strandGPBP1L1TMEM69: 45,688,149–45,718,150, forward strandTMEM69KLHL27: 45,692,370–45,750,805, reverse strandKLHL27MAST2: 45,786,987–46,036,228, forward strandMAST2Diagram of TOE1: 8 exons on the forward strand of chromosome 1Exon 4: 1 known disease-causing siteExon 6: 4 known disease-causing sitesExon 7: 2 known disease-causing sitesExon 8: 3 known disease-causing sitesExon 1: 45,340,170–45,340,304, 135 basesExon 2: 45,341,073–45,341,215, 143 basesExon 3: 45,341,303–45,341,343, 41 basesExon 4: 45,341,473–45,341,569, 97 basesExon 5: 45,341,949–45,342,107, 159 basesExon 6: 45,342,384–45,342,643, 260 basesExon 7: 45,342,843–45,343,002, 160 basesExon 8: 45,343,082–45,343,973, 892 bases123456785′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.9 kb of the gene's 3.8 kb; 1,533 of those bases code for the protein.

How a genome test reads TOE1

12

positions in TOE1 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 3.8 kb of TOE1, introns included, not only the 1.9 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). TOE1 gene: target of EGR1, exonuclease. Retrieved 16 October 2026, from https://dantelabs.com/genes/toe1

Vancouver

Dante Labs. TOE1 gene: target of EGR1, exonuclease [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/toe1

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