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Gene

DLK1

delta like non-canonical Notch ligand 1

Summary

Cytogenetic location
14q32.2
Coordinates
Chromosome 14: 100,726,892–100,738,224 (GRCh38)
Exons
5 exons across 11.3 kb
Protein
383 amino acids
Also known as
FA1, pG2, Pref-1, ZOG, Delta1
MANE Select transcript
ENST00000341267.9NM_003836.7
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Monogenic Precocious Puberty

    • Central precocious puberty

      Early activation of the brain signals that start puberty, including familial forms due to MKRN3, DLK1, KISS1 and KISS1R variants.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Treatment with GnRH analogues can pause puberty until a more typical age.

How DLK1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
Chromosome 14, with a bracket where DLK1 sits. DLK1 and 7 genes near it on chromosome 14, from 100,232,558 to 101,232,557.Chromosome 1414q32.2p13p12p11.2p11.1q11.1q11.2q12q13.1q13.2q13.3q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q31.1q31.2q31.3q32.11q32.12q32.13q32.2q32.31q32.32q32.33100.4 Mb100.6 Mb100.8 Mb101 Mb101.2 MbYY1: 100,238,298–100,282,788, forward strandYY1SLC25A29: 100,291,116–100,306,547, reverse strandSLC25A29SLC25A47: 100,323,156–100,330,421, forward strandSLC25A47WARS1: 100,333,782–100,376,805, reverse strandWARS1WDR25: 100,376,418–100,530,306, forward strandWDR25BEGAIN: 100,537,147–100,587,430, reverse strandBEGAINDLK1: 100,726,892–100,738,224, forward strandDLK1RTL1: 100,879,753–100,903,722, reverse strandRTL1Diagram of DLK1: 5 exons on the forward strand of chromosome 14Exon 1: 100,726,892–100,727,135, 244 basesExon 2: 100,728,396–100,728,459, 64 basesExon 3: 100,728,936–100,729,066, 131 basesExon 4: 100,732,042–100,732,183, 142 basesExon 5: 100,734,149–100,738,224, 4,076 bases123455′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.7 kb of the gene's 11.3 kb; 1,152 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). DLK1 gene: delta like non-canonical Notch ligand 1. Retrieved 17 October 2026, from https://dantelabs.com/genes/dlk1

Vancouver

Dante Labs. DLK1 gene: delta like non-canonical Notch ligand 1 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/dlk1

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