Gene
VPS35L
VPS35 endosomal protein sorting factor like
- HGNC 24641↗(opens in a new tab)
- Ensembl gene ENSG00000103544↗(opens in a new tab)
- NCBI Gene 57020↗(opens in a new tab)
Summary
- Cytogenetic location
- 16p12.3
- Coordinates
- Chromosome 16: 19,555,703–19,701,163 (GRCh38)
- Exons
- 31 exons across 145.5 kb
- Protein
- 963 amino acids
- Also known as
- MGC16824
- Previous symbols
- C16orf62
- MANE Select transcript
- ENST00000417362.7NM_020314.7
- Locus type
- gene with protein product
- Very high
- Confident
- Low
- Very low
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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No Genome Test report reads VPS35L yet. The test sequences your whole genome, so your data includes it all the same.
How VPS35L is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
- Known disease-causing sites
- Stretches short reads find hard
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 3.6 kb of the gene's 145.5 kb; 2,892 of those bases code for the protein.
How a genome test reads VPS35L
3
positions in VPS35L where ClinVar classes a change as pathogenic or likely pathogenic
None of them falls in a region short reads find hard.
A whole genome covers all 145.5 kb of VPS35L, introns included, not only the 3.6 kb of exons.
Traits linked to VPS35L
The Human Phenotype Ontology lists these as features of the rare conditions VPS35L can cause. Each trait's page lists the other genes linked to it.
Abnormality of the cardiovascular system
- Abnormal mitral valve morphology
- Abnormal tricuspid valve morphology
- An opening in the wall separating the top two chambers of the heart
- Hole in center of heart
- Hole in heart wall separating two lower heart chambers
- Narrowing of aortic valve
- Narrowing of pulmonic valve
- Tetralogy of Fallot
Show 1 more trait
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
Cite this page
Dante Labs. (n.d.). VPS35L gene: VPS35 endosomal protein sorting factor like. Retrieved 17 October 2026, from https://dantelabs.com/genes/vps35l
Dante Labs. VPS35L gene: VPS35 endosomal protein sorting factor like [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/vps35l
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