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Gene

MGP

matrix Gla protein

Summary

Cytogenetic location
12p12.3
Coordinates
Chromosome 12: 14,880,864–14,885,854 (GRCh38)
Exons
4 exons across 5 kb
Protein
103 amino acids
MANE Select transcript
ENST00000539261.6NM_000900.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads MGP yet. The test sequences your whole genome, so your data includes it all the same.

How MGP is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
Chromosome 12, with a bracket where MGP sits. MGP and 14 genes near it on chromosome 12, from 14,383,359 to 15,383,358.Chromosome 1212p12.3p13.33p13.32p13.31p13.2p13.1p12.3p12.2p12.1p11.23p11.22p11.21p11.1q11q12q13.11q13.12q13.13q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.31q24.32q24.3314.4 Mb14.6 Mb14.8 Mb15 Mb15.2 MbATF7IP: 14,365,439–14,502,931, forward strandATF7IPPLBD1: 14,503,660–14,567,928, reverse strandPLBD1GUCY2C: 14,612,632–14,696,652, reverse strandGUCY2CH4C16: 14,767,999–14,771,131, reverse strandH4C16H2AJ: 14,774,405–14,778,002, forward strandH2AJWBP11: 14,783,595–14,803,510, reverse strandWBP11C12orf60: 14,802,864–14,906,586, forward strandC12orf60SMCO3: 14,804,065–14,814,189, reverse strandSMCO3ART4: 14,822,378–14,843,630, reverse strandART4MGP: 14,880,864–14,885,854, reverse strandMGPERP27: 14,912,600–14,938,557, reverse strandERP27ARHGDIB: 14,942,009–14,961,985, reverse strandARHGDIBPDE6H: 14,949,827–14,982,699, forward strandPDE6HRERG: 15,107,783–15,390,485, reverse strandRERGPTPRO: 15,322,257–15,602,175, forward strandPTPRODiagram of MGP: 4 exons on the reverse strand of chromosome 12Exon 4: 14,880,864–14,882,280, 1,417 basesExon 3: 14,882,972–14,883,047, 76 basesExon 2: 14,884,213–14,884,245, 33 basesExon 1: 14,885,731–14,885,854, 124 bases43215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.7 kb of the gene's 5 kb; 312 of those bases code for the protein.

How a genome test reads MGP

1

position in MGP where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 5 kb of MGP, introns included, not only the 1.7 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). MGP gene: matrix Gla protein. Retrieved 17 October 2026, from https://dantelabs.com/genes/mgp

Vancouver

Dante Labs. MGP gene: matrix Gla protein [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/mgp

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