Gene
FGF3
fibroblast growth factor 3
- HGNC 3681↗(opens in a new tab)
- Ensembl gene ENSG00000186895↗(opens in a new tab)
- NCBI Gene 2248↗(opens in a new tab)
Summary
- Cytogenetic location
- 11q13.3
- Coordinates
- Chromosome 11: 69,809,968–69,819,416 (GRCh38)
- Exons
- 3 exons across 9.4 kb
- Protein
- 239 amino acids
- Also known as
- HBGF-3
- Previous symbols
- INT2
- MANE Select transcript
- ENST00000334134.4NM_005247.4
- Locus type
- Protein-coding
- Very high
- Confident
- Low
- Very low
This page as data
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No Genome Test report reads FGF3 yet. The test sequences your whole genome, so your data includes it all the same.
How FGF3 is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
- Known disease-causing sites
- Stretches short reads find hard
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 1.5 kb of the gene's 9.4 kb; 720 of those bases code for the protein.
Sequencing FGF3
12
positions in FGF3 where ClinVar classes a change as pathogenic or likely pathogenic
None of them falls in a region short reads find hard.
A whole genome covers all 9.4 kb of FGF3, introns included, not only the 1.5 kb of exons.
Traits linked to FGF3
The Human Phenotype Ontology lists these as features of the rare conditions FGF3 can cause. Each trait's page lists the other genes linked to it.
Abnormality of head or neck
- Decreased size of tooth
- Widely spaced teeth
- Abnormal dental pulp morphology
- Abnormal shape of molar tooth
- Abnormality of canine
- Cone shaped tooth
- Dental cavities
- Abnormal tooth enamel
Show 23 more traits
- Abnormality of the upper jaw bone
- Absence of premolar
- Delayed eruption of teeth
- Downward slanting of the opening between the eyelids
- Full cheeks
- Gum disease
- Gum enlargement
- Jugular foramen stenosis
- Little lower jaw
- Long face
- Long philtrum
- Nasal tip, upturned
- Pointed chin
- Prominent nose
- Pulp stones
- Taurodontia
- Underdeveloped tissue around nostril
- Wide nasal bridge
- Extra teeth
- Failure of development of between one and six teeth
- Monobrow
- Odontoma
- Peg-shaped maxillary lateral incisors
Abnormality of the ear
- Absent inner ear
- Microtia, first degree
- Profound sensorineural hearing impairment
- Anteverted ears
- Hearing impairment
- Progressive sensorineural hearing impairment
- Sensorineural hearing impairment
- Small ears
Show 2 more traits
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
Cite this page
Dante Labs. (n.d.). FGF3 gene: fibroblast growth factor 3. Retrieved 17 October 2026, from https://dantelabs.com/genes/fgf3
Dante Labs. FGF3 gene: fibroblast growth factor 3 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/fgf3
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