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Gene

MED16

mediator complex subunit 16

Summary

Cytogenetic location
19p13.3
Coordinates
Chromosome 19: 867,963–893,187 (GRCh38)
Exons
16 exons across 25.2 kb
Protein
877 amino acids
Also known as
DRIP92, TRAP95
Previous symbols
THRAP5
MANE Select transcript
ENST00000325464.6NM_005481.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads MED16 yet. The test sequences your whole genome, so your data includes it all the same.

How MED16 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 19, with a bracket where MED16 sits. MED16 and 43 genes near it on chromosome 19, from 380,575 to 1,380,574.Chromosome 1919p13.3p13.3p13.2p13.13p13.12p13.11p12p11q11q12q13.11q13.12q13.13q13.2q13.31q13.32q13.33q13.41q13.42q13.430.4 Mb0.6 Mb0.8 Mb1 Mb1.2 MbC2CD4C: 405,443–409,214, reverse strandC2CD4CSHC2: 416,315–461,100, reverse strandSHC2CIMAP1D: 462,728–474,983, reverse strandCIMAP1DMADCAM1: 489,176–505,343, forward strandMADCAM1TPGS1: 507,488–520,846, forward strandTPGS1CDC34: 531,435–542,092, forward strandCDC34GZMM: 544,034–549,924, forward strandGZMMBSG: 571,277–583,498, forward strandBSGHCN2: 589,881–617,159, forward strandHCN2POLRMT: 617,168–633,619, reverse strandPOLRMTFGF22: 639,879–644,373, forward strandFGF22RNF126: 647,526–663,336, reverse strandRNF126FSTL3: 676,366–683,793, forward strandFSTL3PRSS57: 685,546–695,498, reverse strandPRSS57PALM: 708,906–748,329, forward strandPALMMISP: 748,404–764,363, forward strandMISPPTBP1: 797,075–812,327, forward strandPLPPR3: 810,908–822,619, reverse strandAZU1: 825,097–832,018, forward strandAZU1PRTN3: 840,999–848,255, forward strandPRTN3ELANE: 850,951–856,247, forward strandELANECFD: 859,426–869,492, forward strandCFDMED16: 867,963–893,187, reverse strandMED16R3HDM4: 896,503–913,245, reverse strandR3HDM4KISS1R: 917,287–921,005, forward strandKISS1RARID3A: 924,528–975,939, forward strandARID3AWDR18: 984,248–998,438, forward strandWDR18GRIN3B: 1,000,419–1,009,732, forward strandGRIN3BTMEM259: 1,009,615–1,021,270, reverse strandTMEM259CNN2: 1,026,270–1,039,077, forward strandCNN2ABCA7: 1,039,997–1,065,572, forward strandABCA7ARHGAP45: 1,065,923–1,087,829, forward strandARHGAP45POLR2E: 1,085,104–1,095,486, reverse strandPOLR2EGPX4: 1,103,982–1,106,791, forward strandGPX4SBNO2: 1,107,634–1,174,295, reverse strandSBNO2STK11: 1,177,558–1,228,431, forward strandSTK11CBARP: 1,228,282–1,239,465, reverse strandCBARPATP5F1D: 1,241,734–1,244,828, forward strandATP5F1DMIDN: 1,248,316–1,259,145, forward strandMIDNCIRBP: 1,259,384–1,274,880, forward strandCIRBPFAM174C: 1,275,509–1,279,244, forward strandFAM174C: 1,276,021–1,279,244, forward strandEFNA2: 1,285,873–1,301,431, forward strandPWWP3A: 1,354,293–1,378,434, forward strandPWWP3ADiagram of MED16: 16 exons on the reverse strand of chromosome 19Exon 10: 1 known disease-causing siteExon 16: 867,963–868,251, 289 basesExon 15: 868,416–868,499, 84 basesExon 14: 868,863–868,946, 84 basesExon 13: 871,037–871,253, 217 basesExon 12: 871,926–872,118, 193 basesExon 11: 873,449–873,582, 134 basesExon 10: 875,244–875,454, 211 basesExon 9: 876,974–877,180, 207 basesExon 8: 879,937–880,148, 212 basesExon 7: 881,559–881,714, 156 basesExon 6: 884,903–885,008, 106 basesExon 5: 885,770–886,201, 432 basesExon 4: 889,638–889,807, 170 basesExon 3: 890,137–890,244, 108 basesExon 2: 890,963–891,149, 187 basesExon 1: 893,086–893,187, 102 bases16141210864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.9 kb of the gene's 25.2 kb; 2,634 of those bases code for the protein.

How a genome test reads MED16

2

positions in MED16 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 25.2 kb of MED16, introns included, not only the 2.9 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). MED16 gene: mediator complex subunit 16. Retrieved 17 October 2026, from https://dantelabs.com/genes/med16

Vancouver

Dante Labs. MED16 gene: mediator complex subunit 16 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/med16

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