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Gene

LTBP3

latent transforming growth factor beta binding protein 3

Summary

Cytogenetic location
11q13.1
Coordinates
Chromosome 11: 65,538,559–65,558,359 (GRCh38)
Exons
28 exons across 19.8 kb
Protein
1,303 amino acids
Previous symbols
LTBP2
MANE Select transcript
ENST00000301873.11NM_001130144.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads LTBP3 yet. The test sequences your whole genome, so your data includes it all the same.

How LTBP3 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 11, with a bracket where LTBP3 sits. LTBP3 and 49 genes near it on chromosome 11, from 65,048,459 to 66,048,458.Chromosome 1111q13.1p15.5p15.4p15.3p15.2p15.1p14.3p14.2p14.1p13p12p11.2p11.12p11.11q11q12.1q12.2q12.3q13.1q13.2q13.3q13.4q13.5q14.1q14.2q14.3q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q2565.2 Mb65.4 Mb65.6 Mb65.8 Mb66 MbNAALADL1: 65,044,818–65,058,558, reverse strandNAALADL1CDCA5: 65,066,299–65,084,164, reverse strandZFPL1: 65,084,210–65,088,409, forward strandCATSPERH: 65,084,974–65,089,375, reverse strandVPS51: 65,089,324–65,111,862, forward strandTM7SF2: 65,111,845–65,116,677, forward strandZNHIT2: 65,116,403–65,117,701, reverse strandZNHIT2FAU: 65,120,182–65,122,221, reverse strandFAUSYVN1: 65,121,780–65,146,912, reverse strandSYVN1MRPL49: 65,122,183–65,127,371, forward strandMRPL49SPDYC: 65,166,137–65,173,380, forward strandSPDYCCAPN1: 65,180,566–65,212,006, forward strandCAPN1POLA2: 65,261,835–65,305,959, forward strandPOLA2: 65,261,928–65,326,543, forward strandCDC42EP2: 65,298,955–65,322,662, forward strandCDC42EP2DPF2: 65,333,792–65,354,262, forward strandDPF2TIGD3: 65,354,746–65,357,613, forward strandTIGD3SLC25A45: 65,375,186–65,384,550, reverse strandSLC25A45FRMD8: 65,386,592–65,413,526, forward strandFRMD8SCYL1: 65,525,044–65,538,711, forward strandSCYL1LTBP3: 65,538,559–65,558,359, reverse strandLTBP3ZNRD2: 65,570,459–65,574,203, forward strandZNRD2FAM89B: 65,572,349–65,574,199, forward strandFAM89BEHBP1L1: 65,575,943–65,594,089, forward strandKCNK7: 65,592,836–65,595,996, reverse strandKCNK7MAP3K11: 65,597,149–65,615,382, reverse strandPCNX3: 65,615,742–65,637,441, forward strandPCNX3SIPA1: 65,638,086–65,650,930, forward strandSIPA1RELA: 65,653,599–65,663,138, reverse strandRELAKAT5: 65,711,992–65,719,604, forward strandKAT5RNASEH2C: 65,713,901–65,720,988, reverse strandRNASEH2CAP5B1: 65,772,723–65,781,708, reverse strandAP5B1OVOL1: 65,786,714–65,797,219, forward strandOVOL1CFL1: 65,823,022–65,862,026, reverse strandCFL1SNX32: 65,833,664–65,856,896, forward strandSNX32MUS81: 65,857,126–65,867,653, forward strandMUS81EFEMP2: 65,866,300–65,878,497, reverse strandEFEMP2CTSW: 65,879,809–65,883,741, forward strandFIBP: 65,883,740–65,888,532, reverse strandCCDC85B: 65,890,673–65,891,635, forward strandFOSL1: 65,892,049–65,900,573, reverse strandC11orf68: 65,916,810–65,919,137, reverse strandDRAP1: 65,919,258–65,921,565, forward strandDRAP1TSGA10IP: 65,945,480–65,960,217, forward strandTSGA10IPSART1: 65,961,681–65,980,137, forward strandSART1EIF1AD: 65,992,009–66,002,472, reverse strandEIF1ADBANF1: 66,001,832–66,004,170, forward strandBANF1CST6: 66,011,506–66,013,505, forward strandCATSPER1: 66,016,752–66,026,479, reverse strandGAL3ST3: 66,040,748–66,049,502, reverse strandGAL3ST3Diagram of LTBP3: 28 exons on the reverse strand of chromosome 11Exon 28: 1 known disease-causing siteExon 27: 2 known disease-causing sitesExon 26: 3 known disease-causing sitesExon 25: 2 known disease-causing sitesExon 24: 5 known disease-causing sitesExon 23: 2 known disease-causing sitesExon 22: 1 known disease-causing siteExon 21: 1 known disease-causing siteExon 20: 1 known disease-causing siteExon 18: 4 known disease-causing sitesExon 16: 4 known disease-causing sitesExon 15: 4 known disease-causing sitesExon 14: 1 known disease-causing siteExon 13: 4 known disease-causing sitesExon 12: 1 known disease-causing siteExon 11: 2 known disease-causing sitesExon 10: 1 known disease-causing siteExon 8: 3 known disease-causing sitesExon 7: 1 known disease-causing siteExon 6: 2 known disease-causing sitesExon 5: 1 known disease-causing siteExon 4: 1 known disease-causing siteExon 3: 1 known disease-causing siteExon 2: 3 known disease-causing sitesExon 1: 2 known disease-causing sitesExon 28: 65,538,559–65,539,231, 673 basesExon 27: 65,539,328–65,539,459, 132 basesExon 26: 65,539,548–65,539,628, 81 basesExon 25: 65,539,720–65,539,881, 162 basesExon 24: 65,540,013–65,540,153, 141 basesExon 23: 65,540,245–65,540,382, 138 basesExon 22: 65,540,486–65,540,614, 129 basesExon 21: 65,540,871–65,540,954, 84 basesExon 20: 65,541,126–65,541,293, 168 basesExon 19: 65,541,600–65,541,728, 129 basesExon 18: 65,543,105–65,543,224, 120 basesExon 17: 65,543,427–65,543,549, 123 basesExon 16: 65,546,442–65,546,564, 123 basesExon 15: 65,546,798–65,546,920, 123 basesExon 14: 65,547,439–65,547,567, 129 basesExon 13: 65,547,690–65,547,821, 132 basesExon 12: 65,547,920–65,548,045, 126 basesExon 11: 65,551,126–65,551,224, 99 basesExon 10: 65,551,402–65,551,474, 73 basesExon 9: 65,551,548–65,551,564, 17 basesExon 8: 65,551,972–65,552,157, 186 basesExon 7: 65,552,248–65,552,406, 159 basesExon 6: 65,552,860–65,552,982, 123 basesExon 5: 65,553,164–65,553,256, 93 basesExon 4: 65,553,425–65,553,530, 106 basesExon 3: 65,553,701–65,553,903, 203 basesExon 2: 65,554,051–65,554,380, 330 basesExon 1: 65,557,629–65,558,359, 731 bases28262422201816141210864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.8 kb of the gene's 19.8 kb; 3,912 of those bases code for the protein.

How a genome test reads LTBP3

78

positions in LTBP3 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 19.8 kb of LTBP3, introns included, not only the 4.8 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). LTBP3 gene: latent transforming growth factor beta binding protein 3. Retrieved 17 October 2026, from https://dantelabs.com/genes/ltbp3

Vancouver

Dante Labs. LTBP3 gene: latent transforming growth factor beta binding protein 3 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/ltbp3

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