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Gene

WLS

Wnt ligand secretion mediator

Summary

Cytogenetic location
1p31.3
Coordinates
Chromosome 1: 68,125,360–68,232,523 (GRCh38)
Exons
12 exons across 107.2 kb
Protein
541 amino acids
Also known as
FLJ23091, MRP, EVI, mig-14
Previous symbols
C1orf139, GPR177
MANE Select transcript
ENST00000262348.9NM_024911.7
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads WLS yet. The test sequences your whole genome, so your data includes it all the same.

How WLS is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 1, with a bracket where WLS sits. WLS and 5 genes near it on chromosome 1, from 67,678,942 to 68,678,941.Chromosome 11p31.3p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q4467.8 Mb68 Mb68.2 Mb68.4 Mb68.6 MbGADD45A: 67,685,048–67,691,165, forward strandGADD45AGNG12: 67,701,461–67,833,811, reverse strandGNG12DIRAS3: 68,045,513–68,051,717, reverse strandDIRAS3WLS: 68,125,360–68,232,523, reverse strandWLSRPE65: 68,428,822–68,451,103, reverse strandRPE65DEPDC1: 68,474,152–68,497,230, reverse strandDEPDC1Diagram of WLS: 12 exons on the reverse strand of chromosome 1Exon 11: 1 known disease-causing siteExon 9: 1 known disease-causing siteExon 12: 68,125,360–68,126,335, 976 basesExon 11: 68,137,780–68,137,933, 154 basesExon 10: 68,144,569–68,144,652, 84 basesExon 9: 68,145,869–68,146,012, 144 basesExon 8: 68,148,136–68,148,199, 64 basesExon 7: 68,148,563–68,148,660, 98 basesExon 6: 68,150,188–68,150,356, 169 basesExon 5: 68,153,517–68,153,653, 137 basesExon 4: 68,155,099–68,155,260, 162 basesExon 3: 68,159,123–68,159,247, 125 basesExon 2: 68,193,955–68,194,227, 273 basesExon 1: 68,232,194–68,232,523, 330 bases1210864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.7 kb of the gene's 107.2 kb; 1,626 of those bases code for the protein.

How a genome test reads WLS

2

positions in WLS where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 107.2 kb of WLS, introns included, not only the 2.7 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). WLS gene: Wnt ligand secretion mediator. Retrieved 16 October 2026, from https://dantelabs.com/genes/wls

Vancouver

Dante Labs. WLS gene: Wnt ligand secretion mediator [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/wls

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