Gene
IRX5
iroquois homeobox 5
- HGNC 14361↗(opens in a new tab)
- Ensembl gene ENSG00000176842↗(opens in a new tab)
- NCBI Gene 10265↗(opens in a new tab)
Summary
- Cytogenetic location
- 16q12.2
- Coordinates
- Chromosome 16: 54,930,865–54,934,485 (GRCh38)
- Exons
- 3 exons across 3.6 kb
- Protein
- 483 amino acids
- Also known as
- IRX-2a
- MANE Select transcript
- ENST00000394636.9NM_005853.6
- Locus type
- gene with protein product
- Very high
- Confident
- Low
- Very low
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read IRX5, and the rest of your genome, with one test.
From $449Free shipping · Results in 6–8 weeks
Get my Genome TestCurated reports relevant to this gene
No Genome Test report reads IRX5 yet. The test sequences your whole genome, so your data includes it all the same.
How IRX5 is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
- Stretches short reads find hard
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 2.4 kb of the gene's 3.6 kb; 1,452 of those bases code for the protein.
Traits linked to IRX5
The Human Phenotype Ontology lists these as features of the rare conditions IRX5 can cause. Each trait's page lists the other genes linked to it.
Abnormality of head or neck
- Bad bite
- Big midface
- Corners of eye widely separated
- Drooping lower lip
- Failure of development of between one and six teeth
- High palate
- Limited hair on end of eyebrow
- Long philtrum
Show 15 more traits
- Low hairline at back of neck
- Narrow opening between the eyelids
- Nasal tip, upturned
- Smooth philtrum
- Sparse eyebrow
- Sparse eyelashes
- Thin dental enamel
- Wide mouth
- Wide nasal bridge
- Thin red part of the upper lip
- Broad head shape
- Deformity of the skull
- Little lower jaw
- Prominent forehead
- Skin tag in front of the ear
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
Cite this page
Dante Labs. (n.d.). IRX5 gene: iroquois homeobox 5. Retrieved 17 October 2026, from https://dantelabs.com/genes/irx5
Dante Labs. IRX5 gene: iroquois homeobox 5 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/irx5
One test. A lifetime of answers.
From $449Free shipping · Results in 6–8 weeks