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Gene

KIF14

kinesin family member 14

Summary

Cytogenetic location
1q32.1
Coordinates
Chromosome 1: 200,551,500–200,620,751 (GRCh38)
Exons
30 exons across 69.3 kb
Protein
1,648 amino acids
Inheritance
Autosomal recessive
Also known as
KIAA0042
MANE Select transcript
ENST00000367350.5NM_014875.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Meckel Syndrome

    • Autosomal recessive

      A rare, lethal, genetic, multiple congenital anomaly disorder characterized by the triad of brain malformation mainly occipital encephalocele, large polycystic kidneys, and polydactyly as well as associated abnormalities that may include cleft lip/palate, cardiac and genital anomalies, central nervous system (CNS) malformations, liver fibrosis, and bone dysplasia.

      • 1 GenCC submitter rates it definitive or strong

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How KIF14 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 1, with a bracket where KIF14 sits. KIF14 and 8 genes near it on chromosome 1, from 200,086,126 to 201,086,125.Chromosome 11q32.1p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q44200.2 Mb200.4 Mb200.6 Mb200.8 Mb201 MbNR5A2: 200,027,575–200,177,420, forward strandNR5A2ZNF281: 200,400,937–200,410,063, reverse strandZNF281KIF14: 200,551,500–200,620,751, reverse strandKIF14DDX59: 200,623,896–200,670,049, reverse strandDDX59CAMSAP2: 200,738,885–200,860,751, forward strandCAMSAP2GPR25: 200,872,981–200,874,178, forward strandGPR25INAVA: 200,890,995–200,915,742, forward strandINAVAKIF21B: 200,969,390–201,023,726, reverse strandKIF21BCACNA1S: 201,039,512–201,112,464, reverse strandCACNA1SDiagram of KIF14: 30 exons on the reverse strand of chromosome 1Exon 29: 1 known disease-causing siteExon 26: 1 known disease-causing siteExon 25: 5 known disease-causing sitesExon 23: 2 known disease-causing sitesExon 13: 1 known disease-causing siteExon 12: 1 known disease-causing siteExon 11: 1 known disease-causing siteExon 3: 1 known disease-causing siteExon 2: 5 known disease-causing sitesExon 30: 200,551,500–200,553,767, 2,268 basesExon 29: 200,554,468–200,554,606, 139 basesExon 28: 200,555,380–200,555,454, 75 basesExon 27: 200,559,330–200,559,452, 123 basesExon 26: 200,560,722–200,560,880, 159 basesExon 25: 200,565,069–200,565,253, 185 basesExon 24: 200,565,445–200,565,669, 225 basesExon 23: 200,569,911–200,570,005, 95 basesExon 22: 200,575,591–200,575,691, 101 basesExon 21: 200,580,254–200,580,383, 130 basesExon 20: 200,581,201–200,581,294, 94 basesExon 19: 200,586,101–200,586,227, 127 basesExon 18: 200,589,217–200,589,369, 153 basesExon 17: 200,590,125–200,590,272, 148 basesExon 16: 200,592,080–200,592,240, 161 basesExon 15: 200,593,667–200,593,769, 103 basesExon 14: 200,598,237–200,598,421, 185 basesExon 13: 200,600,050–200,600,113, 64 basesExon 12: 200,600,356–200,600,503, 148 basesExon 11: 200,601,896–200,602,068, 173 basesExon 10: 200,603,226–200,603,341, 116 basesExon 9: 200,603,839–200,603,955, 117 basesExon 8: 200,605,283–200,605,390, 108 basesExon 7: 200,605,864–200,605,894, 31 basesExon 6: 200,606,746–200,606,798, 53 basesExon 5: 200,608,830–200,608,928, 99 basesExon 4: 200,614,318–200,614,405, 88 basesExon 3: 200,615,355–200,615,609, 255 basesExon 2: 200,617,612–200,618,838, 1,227 basesExon 1: 200,620,411–200,620,751, 341 bases3028262422201816141210864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 7.3 kb of the gene's 69.3 kb; 4,947 of those bases code for the protein.

How a genome test reads KIF14

20

positions in KIF14 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 69.3 kb of KIF14, introns included, not only the 7.3 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). KIF14 gene: kinesin family member 14. Retrieved 17 October 2026, from https://dantelabs.com/genes/kif14

Vancouver

Dante Labs. KIF14 gene: kinesin family member 14 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/kif14

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