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Gene

TP63

tumor protein p63

Summary

Cytogenetic location
3q28
Coordinates
Chromosome 3: 189,631,389–189,897,276 (GRCh38)
Exons
14 exons across 265.9 kb
Protein
680 amino acids
Inheritance
Autosomal dominant
Also known as
p51, SHFM4, EEC3, p63, p73L, OFC8, KET, p73H, NBP, p53CP, p40
Previous symbols
TP73L, TP53L, TP53CP
MANE Select transcript
ENST00000264731.8NM_003722.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Ectodermal Dysplasias

    • TP63-related ectodermal dysplasia spectrumAutosomal dominant

      TP63 conditions combining ectodermal dysplasia with cleft lip or palate and limb malformations, including AEC, Rapp-Hodgkin, ADULT and EEC syndromes.

      • ClinGen rates the link definitive
      • 5 GenCC submitters rate it definitive or strong
    • Limb-mammary syndromeAutosomal dominant

      A TP63 disorder with hand and foot malformations and underdeveloped breasts or nipples.

      • 1 GenCC submitter rates it definitive or strong

  • Female Infertility

    • Diminished or absent ability of a female to achieve conception.

      • 1 GenCC submitter rates it definitive or strong

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

How TP63 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 3, with a bracket where TP63 sits. TP63 and 2 genes near it on chromosome 3, from 189,264,333 to 190,264,332.Chromosome 33q28p26.3p26.2p26.1p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p14.3p14.2p14.1p13p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13.11q13.12q13.13q13.2q13.31q13.32q13.33q21.1q21.2q21.3q22.1q22.2q22.3q23q24q25.1q25.2q25.31q25.32q25.33q26.1q26.2q26.31q26.32q26.33q27.1q27.2q27.3q28q29189.4 Mb189.6 Mb189.8 Mb190 Mb190.2 MbTPRG1: 188,947,165–189,325,304, forward strandTPRG1TP63: 189,631,389–189,897,276, forward strandTP63P3H2: 189,956,728–190,122,437, reverse strandP3H2Diagram of TP63: 14 exons on the forward strand of chromosome 3Exon 4: 4 known disease-causing sitesExon 5: 5 known disease-causing sitesExon 6: 4 known disease-causing sitesExon 7: 7 known disease-causing sitesExon 8: 4 known disease-causing sitesExon 12: 1 known disease-causing siteExon 13: 3 known disease-causing sitesExon 14: 4 known disease-causing sitesExon 1: 189,631,389–189,631,577, 189 basesExon 2: 189,737,740–189,737,868, 129 basesExon 3: 189,738,642–189,738,774, 133 basesExon 4: 189,808,272–189,808,526, 255 basesExon 5: 189,864,232–189,864,418, 187 basesExon 6: 189,866,682–189,866,797, 116 basesExon 7: 189,867,833–189,867,942, 110 basesExon 8: 189,868,580–189,868,716, 137 basesExon 9: 189,869,324–189,869,406, 83 basesExon 10: 189,872,859–189,872,995, 137 basesExon 11: 189,886,394–189,886,551, 158 basesExon 12: 189,889,340–189,889,484, 145 basesExon 13: 189,890,789–189,890,882, 94 basesExon 14: 189,894,206–189,897,276, 3,071 bases1510145′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.9 kb of the gene's 265.9 kb; 2,043 of those bases code for the protein.

How a genome test reads TP63

35

positions in TP63 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 265.9 kb of TP63, introns included, not only the 4.9 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). TP63 gene: tumor protein p63. Retrieved 16 October 2026, from https://dantelabs.com/genes/tp63

Vancouver

Dante Labs. TP63 gene: tumor protein p63 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/tp63

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