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Gene

KCNH1

potassium voltage-gated channel subfamily H member 1

Summary

Cytogenetic location
1q32.2
Coordinates
Chromosome 1: 210,678,314–211,134,148 (GRCh38)
Exons
11 exons across 455.8 kb
Protein
989 amino acids
Also known as
Kv10.1, eag, h-eag, eag1, hEAG, K(V)10.1
MANE Select transcript
ENST00000271751.10NM_172362.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads KCNH1 yet. The test sequences your whole genome, so your data includes it all the same.

How KCNH1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 1, with a bracket where KCNH1 sits. KCNH1 and 7 genes near it on chromosome 1, from 210,222,479 to 211,589,983.Chromosome 11q32.2p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q44210.4 Mb210.6 Mb210.8 Mb211 Mb211.2 Mb211.4 MbSERTAD4: 210,232,572–210,247,734, forward strandSERTAD4HHAT: 210,328,252–210,677,385, forward strandHHATKCNH1: 210,678,314–211,134,148, reverse strandKCNH1: 211,082,872–211,188,533, reverse strandRCOR3: 211,258,377–211,316,385, forward strandRCOR3TRAF5: 211,326,325–211,375,117, forward strandTRAF5RD3: 211,476,522–211,492,490, reverse strandRD3SLC30A1: 211,571,568–211,579,218, reverse strandSLC30A1Diagram of KCNH1: 11 exons on the reverse strand of chromosome 1Exon 8: 3 known disease-causing sitesExon 7: 6 known disease-causing sitesExon 11: 210,678,314–210,684,138, 5,825 basesExon 10: 210,775,348–210,775,544, 197 basesExon 9: 210,797,508–210,797,760, 253 basesExon 8: 210,803,967–210,804,166, 200 basesExon 7: 210,919,640–210,920,069, 430 basesExon 6: 211,018,783–211,019,256, 474 basesExon 5: 211,082,780–211,082,898, 119 basesExon 4: 211,090,562–211,090,690, 129 basesExon 3: 211,103,496–211,103,602, 107 basesExon 2: 211,107,254–211,107,377, 124 basesExon 1: 211,133,867–211,134,148, 282 bases1110864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 8.1 kb of the gene's 455.8 kb; 2,970 of those bases code for the protein.

How a genome test reads KCNH1

9

positions in KCNH1 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 455.8 kb of KCNH1, introns included, not only the 8.1 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). KCNH1 gene: potassium voltage-gated channel subfamily H member 1. Retrieved 17 October 2026, from https://dantelabs.com/genes/kcnh1

Vancouver

Dante Labs. KCNH1 gene: potassium voltage-gated channel subfamily H member 1 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/kcnh1

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