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Gene

FBXO11

F-box protein 11

Summary

Cytogenetic location
2p16.3
Coordinates
Chromosome 2: 47,806,920–47,906,498 (GRCh38)
Exons
23 exons across 99.6 kb
Protein
927 amino acids
Also known as
FBX11, UBR6
MANE Select transcript
ENST00000403359.8NM_001190274.2
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    How FBXO11 is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    • Stretches short reads find hard
    Chromosome 2, with a bracket where FBXO11 sits. FBXO11 and 5 genes near it on chromosome 2, from 47,356,709 to 48,356,708.Chromosome 22p16.3p25.3p25.2p25.1p24.3p24.2p24.1p23.3p23.2p23.1p22.3p22.2p22.1p21p16.3p16.2p16.1p15p14p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13q14.1q14.2q14.3q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q31.1q31.2q31.3q32.1q32.2q32.3q33.1q33.2q33.3q34q35q36.1q36.2q36.3q37.1q37.2q37.347.4 Mb47.6 Mb47.8 Mb48 Mb48.2 MbEPCAM: 47,345,158–47,387,601, forward strandEPCAMMSH2: 47,403,067–47,663,146, forward strandMSH2KCNK12: 47,509,290–47,570,993, reverse strandKCNK12MSH6: 47,695,530–47,810,109, forward strandMSH6FBXO11: 47,806,920–47,906,498, reverse strandFBXO11FOXN2: 48,314,331–48,379,513, forward strandFOXN2Diagram of FBXO11: 23 exons on the reverse strand of chromosome 2Exon 23: 10 known disease-causing sitesExon 22: 6 known disease-causing sitesExon 21: 2 known disease-causing sitesExon 20: 1 known disease-causing siteExon 18: 9 known disease-causing sitesExon 17: 5 known disease-causing sitesExon 16: 3 known disease-causing sitesExon 15: 1 known disease-causing siteExon 14: 6 known disease-causing sitesExon 13: 8 known disease-causing sitesExon 12: 7 known disease-causing sitesExon 11: 2 known disease-causing sitesExon 10: 1 known disease-causing siteExon 9: 1 known disease-causing siteExon 8: 1 known disease-causing siteExon 5: 4 known disease-causing sitesExon 4: 3 known disease-causing sitesExon 3: 2 known disease-causing sitesExon 2: 1 known disease-causing siteExon 1: 3 known disease-causing sitesExon 23: 47,806,920–47,808,247, 1,328 basesExon 22: 47,808,329–47,808,427, 99 basesExon 21: 47,809,158–47,809,266, 109 basesExon 20: 47,809,600–47,809,707, 108 basesExon 19: 47,810,316–47,810,426, 111 basesExon 18: 47,813,234–47,813,377, 144 basesExon 17: 47,813,791–47,813,867, 77 basesExon 16: 47,818,779–47,818,864, 86 basesExon 15: 47,818,956–47,819,078, 123 basesExon 14: 47,820,362–47,820,456, 95 basesExon 13: 47,822,218–47,822,303, 86 basesExon 12: 47,823,143–47,823,360, 218 basesExon 11: 47,832,349–47,832,486, 138 basesExon 10: 47,832,572–47,832,678, 107 basesExon 9: 47,832,769–47,832,880, 112 basesExon 8: 47,832,964–47,833,070, 107 basesExon 7: 47,834,579–47,834,711, 133 basesExon 6: 47,834,788–47,834,871, 84 basesExon 5: 47,835,872–47,836,001, 130 basesExon 4: 47,838,859–47,839,003, 145 basesExon 3: 47,839,419–47,839,500, 82 basesExon 2: 47,839,642–47,839,769, 128 basesExon 1: 47,905,489–47,906,498, 1,010 bases2315′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 4.8 kb of the gene's 99.6 kb; 2,784 of those bases code for the protein.

    How a genome test reads FBXO11

    93

    positions in FBXO11 where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    A whole genome covers all 99.6 kb of FBXO11, introns included, not only the 4.8 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). FBXO11 gene: F-box protein 11. Retrieved 17 October 2026, from https://dantelabs.com/genes/fbxo11

    Vancouver

    Dante Labs. FBXO11 gene: F-box protein 11 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/fbxo11

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