Skip to content
Use your HSA or FSA funds

Gene

SPEN

spen family transcriptional repressor

Summary

Cytogenetic location
1p36.21-p36.13
Coordinates
Chromosome 1: 15,847,707–15,940,456 (GRCh38)
Exons
15 exons across 92.8 kb
Protein
3,664 amino acids
Also known as
KIAA0929, MINT, SHARP, RBM15C
MANE Select transcript
ENST00000375759.8NM_015001.3
Locus type
gene with protein product

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads SPEN yet. The test sequences your whole genome, so your data includes it all the same.

How SPEN is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 1, with a bracket where SPEN sits. SPEN and 27 genes near it on chromosome 1, from 15,394,082 to 16,394,081.Chromosome 11p36.21-p36.13p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q4415.4 Mb15.6 Mb15.8 Mb16 Mb16.2 MbFHAD1: 15,236,521–15,400,283, forward strandFHAD1EFHD2: 15,409,572–15,430,343, forward strandEFHD2CTRC: 15,438,442–15,449,242, forward strandCTRCCELA2A: 15,456,728–15,472,093, forward strandCELA2ACELA2B: 15,465,909–15,491,400, forward strandCELA2BCASP9: 15,489,724–15,526,534, reverse strandCASP9DNAJC16: 15,526,813–15,592,379, forward strandDNAJC16AGMAT: 15,571,699–15,585,084, reverse strandAGMATDDI2: 15,617,416–15,669,044, forward strandDDI2RSC1A1: 15,659,713–15,662,033, forward strandRSC1A1PLEKHM2: 15,681,461–15,734,771, forward strandPLEKHM2SLC25A34: 15,736,176–15,741,392, forward strandSLC25A34TMEM82: 15,742,488–15,747,982, forward strandTMEM82FBLIM1: 15,756,604–15,786,594, forward strandFBLIM1UQCRHL: 15,807,169–15,809,348, reverse strandUQCRHLSPEN: 15,847,707–15,940,456, forward strandSPENZBTB17: 15,940,148–15,976,132, reverse strandZBTB17SRARP: 16,004,229–16,009,382, forward strandSRARPHSPB7: 16,014,018–16,020,597, reverse strandHSPB7CLCNKA: 16,018,146–16,034,109, forward strandCLCNKACLCNKB: 16,040,252–16,057,367, forward strandCLCNKBFAM131C: 16,057,769–16,073,664, reverse strandEPHA2: 16,124,337–16,156,141, reverse strandEPHA2ARHGEF19: 16,197,854–16,212,893, reverse strandARHGEF19CPLANE2: 16,231,692–16,237,214, reverse strandCPLANE2FBXO42: 16,246,840–16,352,494, reverse strandFBXO42SZRD1: 16,352,575–16,398,147, forward strandSZRD1SPATA21: 16,387,117–16,437,424, reverse strandSPATA21Diagram of SPEN: 15 exons on the forward strand of chromosome 1Exon 2: 1 known disease-causing siteExon 3: 2 known disease-causing sitesExon 4: 3 known disease-causing sitesExon 6: 1 known disease-causing siteExon 11: 41 known disease-causing sitesExon 12: 1 known disease-causing siteExon 1: 15,847,707–15,848,150, 444 basesExon 2: 15,872,816–15,873,136, 321 basesExon 3: 15,876,202–15,876,678, 477 basesExon 4: 15,909,321–15,909,481, 161 basesExon 5: 15,911,101–15,911,301, 201 basesExon 6: 15,916,128–15,916,279, 152 basesExon 7: 15,918,926–15,919,051, 126 basesExon 8: 15,919,404–15,919,517, 114 basesExon 9: 15,920,870–15,920,983, 114 basesExon 10: 15,922,249–15,922,349, 101 basesExon 11: 15,928,091–15,936,266, 8,176 basesExon 12: 15,937,163–15,937,645, 483 basesExon 13: 15,937,812–15,938,006, 195 basesExon 14: 15,938,718–15,938,876, 159 basesExon 15: 15,939,296–15,940,456, 1,161 bases1510155′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 12.4 kb of the gene's 92.8 kb; 10,995 of those bases code for the protein.

How a genome test reads SPEN

50

positions in SPEN where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 92.8 kb of SPEN, introns included, not only the 12.4 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). SPEN gene: spen family transcriptional repressor. Retrieved 17 October 2026, from https://dantelabs.com/genes/spen

Vancouver

Dante Labs. SPEN gene: spen family transcriptional repressor [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/spen

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test