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Gene

HNRNPR

heterogeneous nuclear ribonucleoprotein R

Summary

Cytogenetic location
1p36.12
Coordinates
Chromosome 1: 23,304,688–23,344,284 (GRCh38)
Exons
11 exons across 39.6 kb
Protein
633 amino acids
Also known as
hnRNP-R
Previous symbols
HNRPR
MANE Select transcript
ENST00000302271.11NM_005826.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    • Intellectual Disability

      • One of 233 genes linked to it

        • ClinGen rates the link definitive
        • 1 GenCC submitter rates it definitive or strong

    How HNRNPR is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    • Stretches short reads find hard
    Chromosome 1, with a bracket where HNRNPR sits. HNRNPR and 18 genes near it on chromosome 1, from 22,824,486 to 23,824,485.Chromosome 11p36.12p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q4423 Mb23.2 Mb23.4 Mb23.6 Mb23.8 MbEPHB2: 22,710,798–22,921,500, forward strandEPHB2LACTBL1: 22,953,043–22,972,866, reverse strandLACTBL1TEX46: 23,010,833–23,019,100, reverse strandTEX46KDM1A: 23,019,395–23,083,704, forward strandKDM1ALUZP1: 23,084,030–23,178,152, reverse strandLUZP1: 23,094,326–23,094,376, reverse strandHTR1D: 23,190,178–23,217,547, reverse strandHTR1DHNRNPR: 23,304,688–23,344,284, reverse strandHNRNPRZNF436: 23,359,448–23,369,960, reverse strandZNF436TCEA3: 23,370,591–23,425,169, reverse strandTCEA3ASAP3: 23,428,560–23,484,637, reverse strandASAP3E2F2: 23,506,423–23,531,241, reverse strandE2F2ID3: 23,557,440–23,560,586, reverse strandID3RPL11: 23,691,685–23,698,426, forward strandRPL11ELOA: 23,743,153–23,762,059, forward strandELOAPITHD1: 23,778,365–23,788,232, forward strandPITHD1LYPLA2: 23,791,110–23,795,545, forward strandLYPLA2GALE: 23,795,599–23,800,804, reverse strandGALEHMGCL: 23,801,877–23,838,620, reverse strandHMGCLDiagram of HNRNPR: 11 exons on the reverse strand of chromosome 1Exon 11: 1 known disease-causing siteExon 11: 23,304,688–23,311,066, 6,379 basesExon 10: 23,311,201–23,311,322, 122 basesExon 9: 23,313,553–23,313,702, 150 basesExon 8: 23,318,483–23,318,688, 206 basesExon 7: 23,321,528–23,321,663, 136 basesExon 6: 23,323,556–23,323,732, 177 basesExon 5: 23,333,518–23,333,631, 114 basesExon 4: 23,337,754–23,337,861, 108 basesExon 3: 23,338,490–23,338,608, 119 basesExon 2: 23,340,852–23,341,017, 166 basesExon 1: 23,344,211–23,344,284, 74 bases11109876543215′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 7.8 kb of the gene's 39.6 kb; 1,902 of those bases code for the protein.

    How a genome test reads HNRNPR

    1

    position in HNRNPR where ClinVar classes a change as pathogenic or likely pathogenic

    1 of them (100%) falls in a region short reads find hard.

    • Segmental duplications (1 site)Copies of at least 1 kb sharing at least 90% identity with another part of the genome (paralogues, pseudogenes); reads may align to the wrong copy.

    A whole genome covers all 39.6 kb of HNRNPR, introns included, not only the 7.8 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). HNRNPR gene: heterogeneous nuclear ribonucleoprotein R. Retrieved 17 October 2026, from https://dantelabs.com/genes/hnrnpr

    Vancouver

    Dante Labs. HNRNPR gene: heterogeneous nuclear ribonucleoprotein R [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/hnrnpr

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