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Gene

AGO1

argonaute RISC component 1

Summary

Cytogenetic location
1p34.3
Coordinates
Chromosome 1: 35,883,209–35,930,532 (GRCh38)
Exons
19 exons across 47.3 kb
Protein
857 amino acids
Also known as
hAGO1
Previous symbols
EIF2C1
MANE Select transcript
ENST00000373204.6NM_012199.5
Locus type
Protein-coding
  • Very high
  • Confident
  • Low
  • Very low

Curated reports relevant to this gene

No Genome Test report reads AGO1 yet. The test sequences your whole genome, so your data includes it all the same.

How AGO1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 1, with a bracket where AGO1 sits. AGO1 and 19 genes near it on chromosome 1, from 35,406,871 to 36,406,870.Chromosome 11p34.3p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q4435.6 Mb35.8 Mb36 Mb36.2 Mb36.4 MbZMYM4: 35,268,664–35,423,213, forward strandZMYM4KIAA0319L: 35,393,883–35,557,950, reverse strandKIAA0319LNCDN: 35,557,442–35,567,274, forward strandNCDNTFAP2E: 35,573,309–35,595,590, forward strandTFAP2EPSMB2: 35,599,541–35,641,568, reverse strandPSMB2C1orf216: 35,713,875–35,718,894, reverse strandC1orf216CLSPN: 35,720,202–35,770,002, reverse strandCLSPNAGO4: 35,807,976–35,857,890, forward strandAGO4AGO1: 35,883,209–35,930,532, forward strandAGO1AGO3: 35,930,696–36,072,500, forward strandAGO3TEKT2: 36,084,080–36,088,278, forward strandTEKT2ADPRS: 36,088,873–36,095,461, forward strandADPRSCOL8A2: 36,095,239–36,125,234, reverse strandCOL8A2TRAPPC3: 36,136,570–36,156,053, reverse strandTRAPPC3MAP7D1: 36,155,541–36,180,849, forward strandMAP7D1THRAP3: 36,224,392–36,305,376, forward strandTHRAP3MNMIP1: 36,306,314–36,329,340, forward strandMNMIP1EVA1B: 36,322,030–36,324,154, reverse strandEVA1BSTK40: 36,339,620–36,385,932, reverse strandSTK40LSM10: 36,388,814–36,397,945, reverse strandLSM10Diagram of AGO1: 19 exons on the forward strand of chromosome 1Exon 5: 3 known disease-causing sitesExon 9: 2 known disease-causing sitesExon 10: 1 known disease-causing siteExon 13: 1 known disease-causing siteExon 1: 35,883,209–35,883,446, 238 basesExon 2: 35,888,427–35,888,610, 184 basesExon 3: 35,892,557–35,892,677, 121 basesExon 4: 35,893,097–35,893,278, 182 basesExon 5: 35,893,674–35,893,810, 137 basesExon 6: 35,894,037–35,894,171, 135 basesExon 7: 35,894,315–35,894,402, 88 basesExon 8: 35,895,122–35,895,269, 148 basesExon 9: 35,901,474–35,901,593, 120 basesExon 10: 35,901,948–35,902,070, 123 basesExon 11: 35,902,204–35,902,337, 134 basesExon 12: 35,906,935–35,907,119, 185 basesExon 13: 35,913,842–35,914,001, 160 basesExon 14: 35,914,184–35,914,274, 91 basesExon 15: 35,915,348–35,915,542, 195 basesExon 16: 35,917,593–35,917,727, 135 basesExon 17: 35,918,322–35,918,423, 102 basesExon 18: 35,919,055–35,919,254, 200 basesExon 19: 35,919,499–35,930,532, 11,034 bases124681012141618195′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 13.7 kb of the gene's 47.3 kb; 2,574 of those bases code for the protein.

Sequencing AGO1

7

positions in AGO1 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 47.3 kb of AGO1, introns included, not only the 13.7 kb of exons.

Traits linked to AGO1

The Human Phenotype Ontology lists these as features of the rare conditions AGO1 can cause. Each trait's page lists the other genes linked to it.

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). AGO1 gene: argonaute RISC component 1. Retrieved 18 October 2026, from https://dantelabs.com/genes/ago1

Vancouver

Dante Labs. AGO1 gene: argonaute RISC component 1 [Internet]. [cited 18 October 2026]. Available from: https://dantelabs.com/genes/ago1

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