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Gene

RAB18

RAB18, member RAS oncogene family

Summary

Cytogenetic location
10p12.1
Coordinates
Chromosome 10: 27,504,304–27,542,239 (GRCh38)
Exons
7 exons across 37.9 kb
Protein
206 amino acids
MANE Select transcript
ENST00000356940.11NM_021252.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Microphthalmia, Anophthalmia & Coloboma

    • Syndromic Microphthalmia

      Microphthalmia occurring with features outside the eye, caused by changes in genes such as SOX2, OTX2, BCOR, STRA6 and BMP4.

      • ClinGen rates the link moderate
      • 3 GenCC submitters rate it definitive or strong
      What knowing changes

      A genetic diagnosis guides checks for associated features, such as pituitary hormone problems with SOX2 or OTX2, and informs recurrence risk.

How RAB18 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 10, with a bracket where RAB18 sits. RAB18 and 7 genes near it on chromosome 10, from 27,023,272 to 28,023,271.Chromosome 1010p12.1p15.3p15.2p15.1p14p13p12.33p12.32p12.31p12.2p12.1p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.31q23.32q23.33q24.1q24.2q24.31q24.32q24.33q25.1q25.2q25.3q26.11q26.12q26.13q26.2q26.327.2 Mb27.4 Mb27.6 Mb27.8 Mb28 MbANKRD26: 26,973,793–27,100,520, reverse strandANKRD26YME1L1: 27,107,777–27,155,266, reverse strandYME1L1MASTL: 27,154,425–27,187,953, forward strandMASTLACBD5: 27,168,135–27,243,046, reverse strandACBD5PTCHD3: 27,397,121–27,414,368, reverse strandPTCHD3RAB18: 27,504,304–27,542,239, forward strandRAB18MKX: 27,672,874–27,746,394, reverse strandMKXODAD2: 27,775,186–27,999,532, reverse strandODAD2Diagram of RAB18: 7 exons on the forward strand of chromosome 10Exon 5: 1 known disease-causing siteExon 7: 2 known disease-causing sitesExon 1: 27,504,304–27,504,437, 134 basesExon 2: 27,509,875–27,509,930, 56 basesExon 3: 27,526,828–27,526,889, 62 basesExon 4: 27,532,507–27,532,579, 73 basesExon 5: 27,533,735–27,533,853, 119 basesExon 6: 27,533,928–27,533,994, 67 basesExon 7: 27,537,876–27,542,239, 4,364 bases124675′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.9 kb of the gene's 37.9 kb; 621 of those bases code for the protein.

How a genome test reads RAB18

4

positions in RAB18 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 37.9 kb of RAB18, introns included, not only the 4.9 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). RAB18 gene: RAB18, member RAS oncogene family. Retrieved 16 October 2026, from https://dantelabs.com/genes/rab18

Vancouver

Dante Labs. RAB18 gene: RAB18, member RAS oncogene family [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/rab18

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