Gene
ROR2
ROR family WNT receptor 2
- HGNC 10257↗(opens in a new tab)
- Ensembl gene ENSG00000169071↗(opens in a new tab)
- NCBI Gene 4920↗(opens in a new tab)
Summary
- Cytogenetic location
- 9q22.31
- Coordinates
- Chromosome 9: 91,722,601–91,950,228 (GRCh38)
- Exons
- 9 exons across 227.6 kb
- Protein
- 943 amino acids
- Previous symbols
- NTRKR2, BDB, BDB1
- MANE Select transcript
- ENST00000375708.4NM_004560.4
- Locus type
- gene with protein product
- Very high
- Confident
- Low
- Very low
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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No Genome Test report reads ROR2 yet. The test sequences your whole genome, so your data includes it all the same.
How ROR2 is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
- Known disease-causing sites
- Stretches short reads find hard
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 4.2 kb of the gene's 227.6 kb; 2,832 of those bases code for the protein.
How a genome test reads ROR2
25
positions in ROR2 where ClinVar classes a change as pathogenic or likely pathogenic
None of them falls in a region short reads find hard.
A whole genome covers all 227.6 kb of ROR2, introns included, not only the 4.2 kb of exons.
Traits linked to ROR2
The Human Phenotype Ontology lists these as features of the rare conditions ROR2 can cause. Each trait's page lists the other genes linked to it.
Abnormality of head or neck
- Short nose
- Abnormal dentition
- Downturned corners of mouth
- Midface retrusion
- Nasal tip, upturned
- Open bite
- Prominent forehead
- Wide mouth
Show 36 more traits
- Wide nasal bridge
- Abnormally small tongue
- Big calvaria
- Broad opening between the eyelids
- Cleft tongue
- Decreased number of teeth
- Depressed nasal bridge
- Downward slanting of the opening between the eyelids
- Eye folds
- Frontal bossing
- Gum enlargement
- Little lower jaw
- Long eyelashes
- Long philtrum
- Narrow palate
- Receding chin
- Short neck
- Tented mouth
- Thin red part of the upper lip
- Tongue tied
- Triangular mouth
- Upward slanting of the opening between the eyelids
- Abnormality of the palate
- Cleft of the mouth
- Exaggerated cupid's bow
- Extra teeth
- Failure of development of between one and six teeth
- Short philtrum
- Abnormally large tongue
- Absent uvula
- Delayed cranial suture closure
- Delayed eruption of permanent teeth
- Dental crowding
- Flat face
- Wider-than-typical soft spot of skull
- Zygomatic flattening
Abnormality of limbs
- Disproportionately short middle portion of limb
- Fused innermost and middle bones of little finger
- Short fingers or toes
- Absent/small outermost finger bone of the hand
- Curvature of digit
- Curvature of little finger
- Short outermost finger bone
- Short palm
Show 34 more traits
- Bilateral ulnar hypoplasia
- Bowing of outer large bone of the forearm
- Broad big toe
- Broad bone of big toe
- Broad thumb
- Dislocated radial head
- Elbow dislocation
- Limited pronation/supination of forearm
- Mesomelic arm shortening
- Single interphalangeal crease of fifth finger
- Underdeveloped outer large forearm bone
- Bilateral single transverse palmar creases
- Finger syndactyly
- Fused toes
- Fusion of wrist bones
- Gap between 1st and 2nd toes
- Hip dislocation
- Permanent flexion of the finger
- Single transverse palmar crease
- Split hand
- Webbed fingers
- Webbed fingers or toes
- Absent/small long bones of hand
- Absent/small outermost bones of toe
- Broad toe
- Duplication of the outermost bone of hand
- Joint contracture of the hand
- Notched outermost bones of toes
- Radial deviation of finger
- Short digit
- Short middle bone of finger
- Short middle bone of the little finger
- Small hand
- Type B brachydactyly
Abnormality of the genitourinary system
- Short penis
- Underdeveloped penis
- Hydronephrosis
- Increased calcium level in kidney
- Kidney stone
- Underdeveloped female external genitalia
- Underdeveloped inner lips
- Undescended testes
Show 4 more traits
Abnormality of the integument
- Small nail
- Abnormal fingernail development
- Atypical nail growth
- Beauty mark
- Hair loss
- port-wine stain
- Spinal dimple
- Absent nails
Show 1 more trait
Abnormality of the cardiovascular system
- Abnormal aortic morphology
- Abnormal pulmonary valve morphology
- Abnormal tricuspid valve morphology
- Abnormality of the heart
- An opening in the wall separating the top two chambers of the heart
- Hole in heart wall separating two lower heart chambers
- Tetralogy of Fallot
- Right ventricular outlet tract obstruction
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
Cite this page
Dante Labs. (n.d.). ROR2 gene: ROR family WNT receptor 2. Retrieved 16 October 2026, from https://dantelabs.com/genes/ror2
Dante Labs. ROR2 gene: ROR family WNT receptor 2 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/ror2
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