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Gene

KCNN3

potassium calcium-activated channel subfamily N member 3

Summary

Cytogenetic location
1q21.3
Coordinates
Chromosome 1: 154,697,455–154,870,281 (GRCh38)
Exons
8 exons across 172.8 kb
Protein
731 amino acids
Also known as
KCa2.3, hSK3, SKCA3
MANE Select transcript
ENST00000271915.9NM_002249.6
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads KCNN3 yet. The test sequences your whole genome, so your data includes it all the same.

How KCNN3 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 1, with a bracket where KCNN3 sits. KCNN3 and 36 genes near it on chromosome 1, from 154,283,868 to 155,283,867.Chromosome 11q21.3p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q44154.4 Mb154.6 Mb154.8 Mb155 Mb155.2 MbAQP10: 154,321,090–154,325,329, forward strandAQP10ATP8B2: 154,325,511–154,351,307, forward strandATP8B2IL6R: 154,405,141–154,469,450, forward strandIL6RSHE: 154,469,637–154,502,866, reverse strandSHETDRD10: 154,501,508–154,548,147, forward strandTDRD10UBE2Q1: 154,548,550–154,559,028, reverse strandUBE2Q1CHRNB2: 154,567,771–154,580,013, forward strandCHRNB2ADAR: 154,581,695–154,628,013, reverse strandADARKCNN3: 154,697,455–154,870,281, reverse strandKCNN3PMVK: 154,924,732–154,937,008, reverse strandPMVKPBXIP1: 154,944,059–154,956,451, reverse strandPBXIP1PYGO2: 154,957,025–154,963,853, reverse strandPYGO2SHC1: 154,962,284–154,974,452, reverse strandSHC1CKS1B: 154,974,641–154,979,256, forward strandFLAD1: 154,983,311–154,993,111, forward strandLENEP: 154,993,586–154,994,315, forward strandZBTB7B: 155,002,543–155,018,525, forward strandDCST2: 155,018,520–155,033,781, reverse strandDCST2DCST1: 155,033,824–155,050,930, forward strandDCST1ADAM15: 155,050,566–155,062,780, forward strandADAM15EFNA4: 155,063,718–155,069,553, forward strandEFNA4EFNA4-EFNA3: 155,063,748–155,086,807, forward strandEFNA3: 155,078,823–155,087,538, forward strandEFNA3EFNA1: 155,127,452–155,134,899, forward strandEFNA1SLC50A1: 155,135,344–155,138,857, forward strandSLC50A1DPM3: 155,138,457–155,140,595, reverse strandDPM3KRTCAP2: 155,169,182–155,173,475, reverse strandKRTCAP2: 155,169,409–155,187,272, reverse strandTRIM46: 155,173,787–155,184,971, forward strandMUC1: 155,185,824–155,192,916, reverse strandMUC1THBS3: 155,195,584–155,209,203, reverse strandMTX1: 155,208,695–155,213,824, forward strandGBA1: 155,231,270–155,245,178, reverse strandGBA1ENTREP3: 155,247,205–155,255,824, reverse strandENTREP3SCAMP3: 155,255,979–155,262,433, reverse strandSCAMP3CLK2: 155,262,747–155,278,491, reverse strandCLK2HCN3: 155,277,328–155,289,848, forward strandDiagram of KCNN3: 8 exons on the reverse strand of chromosome 1Exon 5: 2 known disease-causing sitesExon 8: 154,697,455–154,708,272, 10,818 basesExon 7: 154,713,464–154,713,533, 70 basesExon 6: 154,714,876–154,715,003, 128 basesExon 5: 154,725,916–154,726,026, 111 basesExon 4: 154,733,003–154,733,144, 142 basesExon 3: 154,771,975–154,772,393, 419 basesExon 2: 154,822,089–154,822,184, 96 basesExon 1: 154,869,032–154,870,281, 1,250 bases864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 13 kb of the gene's 172.8 kb; 2,196 of those bases code for the protein.

How a genome test reads KCNN3

2

positions in KCNN3 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 172.8 kb of KCNN3, introns included, not only the 13 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). KCNN3 gene: potassium calcium-activated channel subfamily N member 3. Retrieved 17 October 2026, from https://dantelabs.com/genes/kcnn3

Vancouver

Dante Labs. KCNN3 gene: potassium calcium-activated channel subfamily N member 3 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/kcnn3

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