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Gene

FREM1

FRAS1 related extracellular matrix 1

Summary

Cytogenetic location
9p22.3
Coordinates
Chromosome 9: 14,737,152–14,910,428 (GRCh38)
Exons
37 exons across 173.3 kb
Protein
2,179 amino acids
Also known as
FLJ25461, C9orf145, C9orf143, DKFZp686M16108, TILRR
Previous symbols
C9orf154
MANE Select transcript
ENST00000380880.4NM_001379081.2
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads FREM1 yet. The test sequences your whole genome, so your data includes it all the same.

How FREM1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 9, with a bracket where FREM1 sits. FREM1 and 4 genes near it on chromosome 9, from 14,323,790 to 15,323,789.Chromosome 99p22.3p24.3p24.2p24.1p23p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q13q21.11q21.12q21.13q21.2q21.31q21.32q21.33q22.1q22.2q22.31q22.32q22.33q31.1q31.2q31.3q32q33.1q33.2q33.3q34.11q34.12q34.13q34.2q34.314.4 Mb14.6 Mb14.8 Mb15 Mb15.2 MbNFIB: 14,081,843–14,398,983, reverse strandNFIBZDHHC21: 14,586,766–14,694,198, reverse strandZDHHC21CER1: 14,717,327–14,722,740, reverse strandCER1FREM1: 14,737,152–14,910,428, reverse strandFREM1TTC39B: 15,163,622–15,307,360, reverse strandTTC39BDiagram of FREM1: 37 exons on the reverse strand of chromosome 9Exon 37: 1 known disease-causing siteExon 34: 2 known disease-causing sitesExon 33: 1 known disease-causing siteExon 31: 1 known disease-causing siteExon 28: 1 known disease-causing siteExon 25: 2 known disease-causing sitesExon 24: 1 known disease-causing siteExon 23: 1 known disease-causing siteExon 22: 2 known disease-causing sitesExon 21: 2 known disease-causing sitesExon 18: 1 known disease-causing siteExon 16: 5 known disease-causing sitesExon 15: 1 known disease-causing siteExon 13: 1 known disease-causing siteExon 12: 1 known disease-causing siteExon 11: 2 known disease-causing sitesExon 9: 3 known disease-causing sitesExon 6: 1 known disease-causing siteExon 5: 1 known disease-causing siteExon 4: 2 known disease-causing sitesExon 2: 1 known disease-causing siteExon 37: 14,737,152–14,737,595, 444 basesExon 36: 14,740,149–14,740,234, 86 basesExon 35: 14,746,353–14,746,468, 116 basesExon 34: 14,746,923–14,747,051, 129 basesExon 33: 14,747,264–14,747,428, 165 basesExon 32: 14,747,681–14,747,728, 48 basesExon 31: 14,748,401–14,748,639, 239 basesExon 30: 14,750,127–14,750,276, 150 basesExon 29: 14,756,374–14,756,446, 73 basesExon 28: 14,759,772–14,759,901, 130 basesExon 27: 14,769,724–14,769,868, 145 basesExon 26: 14,770,605–14,770,806, 202 basesExon 25: 14,775,789–14,776,203, 415 basesExon 24: 14,784,370–14,784,634, 265 basesExon 23: 14,788,919–14,789,114, 196 basesExon 22: 14,792,743–14,792,884, 142 basesExon 21: 14,797,498–14,797,642, 145 basesExon 20: 14,801,652–14,801,874, 223 basesExon 19: 14,804,956–14,805,152, 197 basesExon 18: 14,806,661–14,806,846, 186 basesExon 17: 14,807,940–14,808,134, 195 basesExon 16: 14,812,812–14,813,064, 253 basesExon 15: 14,816,778–14,816,871, 94 basesExon 14: 14,819,234–14,819,442, 209 basesExon 13: 14,823,160–14,823,327, 168 basesExon 12: 14,824,025–14,824,115, 91 basesExon 11: 14,824,796–14,824,992, 197 basesExon 10: 14,841,447–14,841,589, 143 basesExon 9: 14,842,316–14,842,660, 345 basesExon 8: 14,845,960–14,846,091, 132 basesExon 7: 14,848,665–14,848,773, 109 basesExon 6: 14,851,284–14,851,607, 324 basesExon 5: 14,857,553–14,857,749, 197 basesExon 4: 14,859,183–14,859,484, 302 basesExon 3: 14,863,809–14,863,903, 95 basesExon 2: 14,868,744–14,869,244, 501 basesExon 1: 14,909,914–14,910,428, 515 bases3730201015′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 7.6 kb of the gene's 173.3 kb; 6,540 of those bases code for the protein.

How a genome test reads FREM1

43

positions in FREM1 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 173.3 kb of FREM1, introns included, not only the 7.6 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). FREM1 gene: FRAS1 related extracellular matrix 1. Retrieved 16 October 2026, from https://dantelabs.com/genes/frem1

Vancouver

Dante Labs. FREM1 gene: FRAS1 related extracellular matrix 1 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/frem1

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