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Gene

FLNA

filamin A

Summary

Cytogenetic location
Xq28
Coordinates
Chromosome X: 154,348,531–154,374,634 (GRCh38)
Exons
48 exons across 26.1 kb
Protein
2,647 amino acids
Inheritance
X-linked recessive
Also known as
ABP-280
Previous symbols
FLN1, FLN, OPD2, OPD1
MANE Select transcript
ENST00000369850.10NM_001110556.2
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Hereditary Visceral Myopathy, CIPO & MMIHS

    • Chronic intestinal pseudo-obstruction (CIPO)

      Recurrent episodes of bowel obstruction without a physical blockage, including X-linked forms caused by FLNA and recessive forms caused by ERBB3.

      • 2 GenCC submitters rate it definitive or strong
      What knowing changes

      Recognising the condition avoids repeated surgery for suspected blockage and focuses care on nutrition and symptom control.

  • Inherited Congenital Heart Defects

    • X-Linked Cardiac Valvular DysplasiaX-linked recessive

      A condition caused by changes in FLNA in which the heart valves are thickened and leaky, mainly affecting males.

      • 1 GenCC submitter rates it definitive or strong

Broader groupings

  • Epilepsy (Full Panel)

    • Epilepsy

      One of 171 genes linked to it

      A brain disorder characterized by episodes of abnormally increased neuronal discharge resulting in transient episodes of sensory or motor neurological dysfunction, or psychic dysfunction. These episodes may or may not be associated with loss of consciousness or convulsions.

      • 1 GenCC submitter rates it definitive or strong

Inheritance

X-linked recessive
The change is on the X chromosome, so one copy affects males, who have one X, while females with one are usually carriers. A carrier mother passes it on to each child with a one-in-two chance.

How FLNA is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome X, with a bracket where FLNA sits. FLNA and 38 genes near it on chromosome X, from 153,861,583 to 154,861,582.Chromosome XXq28p22.33p22.32p22.31p22.2p22.13p22.12p22.11p21.3p21.2p21.1p11.4p11.3p11.23p11.22p11.21p11.1q11.1q11.2q12q13.1q13.2q13.3q21.1q21.2q21.31q21.32q21.33q22.1q22.2q22.3q23q24q25q26.1q26.2q26.3q27.1q27.2q27.3q28154 Mb154.2 Mb154.4 Mb154.6 Mb154.8 MbL1CAM: 153,861,511–153,886,204, reverse strandL1CAM: 153,872,221–153,909,223, reverse strandAVPR2: 153,902,531–153,907,169, forward strandAVPR2ARHGAP4: 153,907,367–153,934,999, reverse strandNAA10: 153,928,799–153,935,083, reverse strandNAA10RENBP: 153,935,269–153,944,688, reverse strandRENBPHCFC1: 153,946,434–153,972,427, reverse strandHCFC1TMEM187: 153,972,290–153,983,194, forward strandTMEM187IRAK1: 154,010,501–154,020,650, reverse strandIRAK1MECP2: 154,021,573–154,137,103, reverse strandMECP2OPN1LW: 154,144,243–154,159,032, forward strandOPN1LWOPN1MW: 154,182,596–154,196,861, forward strandOPN1MWOPN1MW2: 154,219,756–154,233,286, forward strandOPN1MW2OPN1MW3: 154,257,582–154,271,090, forward strandOPN1MW3TEX28: 154,271,265–154,295,853, reverse strandTEX28TKTL1: 154,295,795–154,330,350, forward strandTKTL1FLNA: 154,348,531–154,374,634, reverse strandFLNAEMD: 154,379,205–154,381,574, forward strandEMDRPL10: 154,389,955–154,409,168, forward strandRPL10DNASE1L1: 154,401,236–154,412,119, reverse strandDNASE1L1TAFAZZIN: 154,409,456–154,421,726, forward strandATP6AP1: 154,428,618–154,436,517, forward strandGDI1: 154,436,600–154,443,467, forward strandGDI1FAM50A: 154,444,103–154,450,655, forward strandPLXNA3: 154,458,275–154,477,779, forward strandPLXNA3LAGE3: 154,477,598–154,479,291, reverse strandLAGE3UBL4A: 154,483,717–154,486,661, reverse strandUBL4ASLC10A3: 154,487,306–154,490,690, reverse strandFAM3A: 154,505,019–154,516,882, reverse strandG6PD: 154,517,825–154,547,584, reverse strandG6PDIKBKG: 154,541,179–154,568,543, forward strandIKBKGCTAG1A: 154,585,133–154,586,816, forward strandCTAG1ACTAG1B: 154,617,609–154,619,282, reverse strandCTAG1BCTAG2: 154,651,972–154,653,579, reverse strandCTAG2GAB3: 154,675,249–154,751,583, reverse strandGAB3DKC1: 154,762,741–154,777,697, forward strandDKC1MPP1: 154,778,684–154,821,039, reverse strandMPP1SMIM9: 154,823,348–154,834,662, reverse strandSMIM9F8: 154,835,788–155,026,940, reverse strandF8Diagram of FLNA: 48 exons on the reverse strand of chromosome XExon 48: 7 known disease-causing sitesExon 47: 4 known disease-causing sitesExon 46: 4 known disease-causing sitesExon 45: 4 known disease-causing sitesExon 44: 2 known disease-causing sitesExon 43: 3 known disease-causing sitesExon 42: 3 known disease-causing sitesExon 41: 9 known disease-causing sitesExon 40: 3 known disease-causing sitesExon 39: 3 known disease-causing sitesExon 38: 2 known disease-causing sitesExon 37: 3 known disease-causing sitesExon 36: 2 known disease-causing sitesExon 35: 2 known disease-causing sitesExon 33: 2 known disease-causing sitesExon 32: 2 known disease-causing sitesExon 31: 12 known disease-causing sitesExon 29: 5 known disease-causing sitesExon 28: 3 known disease-causing sitesExon 27: 1 known disease-causing siteExon 26: 1 known disease-causing siteExon 25: 1 known disease-causing siteExon 24: 3 known disease-causing sitesExon 23: 4 known disease-causing sitesExon 22: 11 known disease-causing sitesExon 21: 4 known disease-causing sitesExon 20: 2 known disease-causing sitesExon 19: 3 known disease-causing sitesExon 18: 1 known disease-causing siteExon 17: 2 known disease-causing sitesExon 16: 3 known disease-causing sitesExon 15: 3 known disease-causing sitesExon 14: 3 known disease-causing sitesExon 13: 6 known disease-causing sitesExon 12: 3 known disease-causing sitesExon 11: 2 known disease-causing sitesExon 10: 2 known disease-causing sitesExon 9: 1 known disease-causing siteExon 8: 8 known disease-causing sitesExon 7: 7 known disease-causing sitesExon 6: 1 known disease-causing siteExon 5: 5 known disease-causing sitesExon 4: 3 known disease-causing sitesExon 3: 9 known disease-causing sitesExon 2: 15 known disease-causing sitesExon 48: 154,348,531–154,349,036, 506 basesExon 47: 154,349,362–154,349,565, 204 basesExon 46: 154,349,649–154,349,867, 219 basesExon 45: 154,350,031–154,350,207, 177 basesExon 44: 154,350,909–154,351,041, 133 basesExon 43: 154,351,581–154,351,696, 116 basesExon 42: 154,351,884–154,352,021, 138 basesExon 41: 154,352,181–154,352,447, 267 basesExon 40: 154,352,553–154,352,675, 123 basesExon 39: 154,352,772–154,352,924, 153 basesExon 38: 154,353,001–154,353,204, 204 basesExon 37: 154,353,296–154,353,457, 162 basesExon 36: 154,353,554–154,353,727, 174 basesExon 35: 154,353,915–154,354,043, 129 basesExon 34: 154,354,151–154,354,291, 141 basesExon 33: 154,354,381–154,354,483, 103 basesExon 32: 154,354,616–154,354,711, 96 basesExon 31: 154,354,825–154,355,072, 248 basesExon 30: 154,357,251–154,357,274, 24 basesExon 29: 154,357,434–154,357,623, 190 basesExon 28: 154,358,199–154,358,355, 157 basesExon 27: 154,358,445–154,358,568, 124 basesExon 26: 154,358,984–154,359,154, 171 basesExon 25: 154,359,246–154,359,406, 161 basesExon 24: 154,359,484–154,359,646, 163 basesExon 23: 154,359,732–154,359,905, 174 basesExon 22: 154,359,990–154,360,587, 598 basesExon 21: 154,361,308–154,361,570, 263 basesExon 20: 154,361,670–154,361,787, 118 basesExon 19: 154,361,979–154,362,148, 170 basesExon 18: 154,362,242–154,362,332, 91 basesExon 17: 154,362,418–154,362,578, 161 basesExon 16: 154,362,661–154,362,784, 124 basesExon 15: 154,364,022–154,364,165, 144 basesExon 14: 154,364,259–154,364,372, 114 basesExon 13: 154,364,526–154,364,719, 194 basesExon 12: 154,364,821–154,364,957, 137 basesExon 11: 154,365,136–154,365,259, 124 basesExon 10: 154,365,349–154,365,486, 138 basesExon 9: 154,366,024–154,366,224, 201 basesExon 8: 154,366,308–154,366,470, 163 basesExon 7: 154,366,562–154,366,639, 78 basesExon 6: 154,366,732–154,366,850, 119 basesExon 5: 154,367,397–154,367,544, 148 basesExon 4: 154,367,641–154,367,738, 98 basesExon 3: 154,367,842–154,368,090, 249 basesExon 2: 154,370,873–154,371,361, 489 basesExon 1: 154,374,506–154,374,634, 129 bases484540353025201510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 8.5 kb of the gene's 26.1 kb; 7,944 of those bases code for the protein.

How a genome test reads FLNA

213

positions in FLNA where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 26.1 kb of FLNA, introns included, not only the 8.5 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). FLNA gene: filamin A. Retrieved 16 October 2026, from https://dantelabs.com/genes/flna

Vancouver

Dante Labs. FLNA gene: filamin A [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/flna

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