Skip to content
Use your HSA or FSA funds

Gene

MED13L

mediator complex subunit 13L

Summary

Cytogenetic location
12q24.21
Coordinates
Chromosome 12: 115,958,576–116,277,693 (GRCh38)
Exons
31 exons across 319.1 kb
Protein
2,210 amino acids
Also known as
KIAA1025, TRAP240L
Previous symbols
THRAP2
MANE Select transcript
ENST00000281928.9NM_015335.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    • Intellectual Disability

      • One of 233 genes linked to it

        • ClinGen rates the link definitive
        • 5 GenCC submitters rate it definitive or strong

    How MED13L is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    • Stretches short reads find hard
    Chromosome 12, with a bracket where MED13L sits. MED13L and 1 gene near it on chromosome 12, from 115,618,135 to 116,618,134.Chromosome 1212q24.21p13.33p13.32p13.31p13.2p13.1p12.3p12.2p12.1p11.23p11.22p11.21p11.1q11q12q13.11q13.12q13.13q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.31q24.32q24.33115.8 Mb116 Mb116.2 Mb116.4 Mb116.6 MbMED13L: 115,958,576–116,277,693, reverse strandMED13LMAP1LC3B2: 116,548,105–116,576,606, forward strandMAP1LC3B2Diagram of MED13L: 31 exons on the reverse strand of chromosome 12Exon 31: 1 known disease-causing siteExon 30: 2 known disease-causing sitesExon 29: 5 known disease-causing sitesExon 28: 2 known disease-causing sitesExon 27: 4 known disease-causing sitesExon 26: 1 known disease-causing siteExon 25: 3 known disease-causing sitesExon 24: 5 known disease-causing sitesExon 23: 3 known disease-causing sitesExon 22: 5 known disease-causing sitesExon 21: 3 known disease-causing sitesExon 20: 3 known disease-causing sitesExon 19: 8 known disease-causing sitesExon 18: 5 known disease-causing sitesExon 17: 18 known disease-causing sitesExon 16: 2 known disease-causing sitesExon 15: 9 known disease-causing sitesExon 14: 1 known disease-causing siteExon 13: 1 known disease-causing siteExon 12: 2 known disease-causing sitesExon 11: 5 known disease-causing sitesExon 10: 5 known disease-causing sitesExon 9: 2 known disease-causing sitesExon 8: 1 known disease-causing siteExon 7: 1 known disease-causing siteExon 6: 6 known disease-causing sitesExon 5: 3 known disease-causing sitesExon 4: 3 known disease-causing sitesExon 3: 5 known disease-causing sitesExon 2: 7 known disease-causing sitesExon 1: 3 known disease-causing sitesExon 31: 115,958,576–115,961,398, 2,823 basesExon 30: 115,963,407–115,963,519, 113 basesExon 29: 115,966,082–115,966,243, 162 basesExon 28: 115,968,940–115,969,097, 158 basesExon 27: 115,970,594–115,970,770, 177 basesExon 26: 115,972,078–115,972,236, 159 basesExon 25: 115,975,171–115,975,313, 143 basesExon 24: 115,975,515–115,975,738, 224 basesExon 23: 115,980,750–115,980,938, 189 basesExon 22: 115,982,384–115,982,603, 220 basesExon 21: 115,983,117–115,983,540, 424 basesExon 20: 115,984,180–115,984,372, 193 basesExon 19: 115,986,266–115,986,489, 224 basesExon 18: 115,987,109–115,987,288, 180 basesExon 17: 115,991,020–115,991,957, 938 basesExon 16: 115,996,476–115,996,681, 206 basesExon 15: 115,997,010–115,997,230, 221 basesExon 14: 116,003,003–116,003,102, 100 basesExon 13: 116,005,869–116,005,993, 125 basesExon 12: 116,006,306–116,006,411, 106 basesExon 11: 116,007,411–116,007,636, 226 basesExon 10: 116,008,401–116,009,132, 732 basesExon 9: 116,012,797–116,012,901, 105 basesExon 8: 116,015,109–116,015,274, 166 basesExon 7: 116,019,224–116,019,412, 189 basesExon 6: 116,019,778–116,019,972, 195 basesExon 5: 116,022,456–116,022,601, 146 basesExon 4: 116,096,669–116,096,752, 84 basesExon 3: 116,111,428–116,111,512, 85 basesExon 2: 116,237,468–116,237,705, 238 basesExon 1: 116,277,060–116,277,693, 634 bases312015′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 9.9 kb of the gene's 319.1 kb; 6,633 of those bases code for the protein.

    How a genome test reads MED13L

    137

    positions in MED13L where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    A whole genome covers all 319.1 kb of MED13L, introns included, not only the 9.9 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). MED13L gene: mediator complex subunit 13L. Retrieved 17 October 2026, from https://dantelabs.com/genes/med13l

    Vancouver

    Dante Labs. MED13L gene: mediator complex subunit 13L [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/med13l

    One test. A lifetime of answers.

    From $449Free shipping · Results in 6–8 weeks

    Get my Genome Test