Skip to content
Use your HSA or FSA funds

Gene

RPL15

ribosomal protein L15

Summary

Cytogenetic location
3p24.2
Coordinates
Chromosome 3: 23,917,132–23,920,989 (GRCh38)
Exons
4 exons across 3.9 kb
Protein
204 amino acids
Inheritance
Autosomal dominant
Also known as
RPL10, RPLY10, RPYL10, EC45, L15, eL15
MANE Select transcript
ENST00000307839.10NM_002948.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Diamond-Blackfan Anemia

    • Autosomal dominant

      A congenital aregenerative and often macrocytic anemia with erythroblastopenia.

      • 2 GenCC submitters rate it definitive or strong

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

How RPL15 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 3, with a bracket where RPL15 sits. RPL15 and 5 genes near it on chromosome 3, from 23,419,061 to 24,419,060.Chromosome 33p24.2p26.3p26.2p26.1p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p14.3p14.2p14.1p13p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13.11q13.12q13.13q13.2q13.31q13.32q13.33q21.1q21.2q21.3q22.1q22.2q22.3q23q24q25.1q25.2q25.31q25.32q25.33q26.1q26.2q26.31q26.32q26.33q27.1q27.2q27.3q28q2923.6 Mb23.8 Mb24 Mb24.2 Mb24.4 MbUBE2E2: 23,203,015–23,592,847, forward strandUBE2E2UBE2E1: 23,805,907–23,892,208, forward strandUBE2E1NKIRAS1: 23,885,033–23,946,591, reverse strandNKIRAS1RPL15: 23,917,132–23,920,989, forward strandRPL15NR1D2: 23,945,258–23,996,741, forward strandNR1D2THRB: 24,117,153–24,495,756, reverse strandTHRBDiagram of RPL15: 4 exons on the forward strand of chromosome 3Exon 2: 1 known disease-causing siteExon 4: 1 known disease-causing siteExon 1: 23,917,132–23,917,173, 42 basesExon 2: 23,917,850–23,918,031, 182 basesExon 3: 23,918,440–23,918,576, 137 basesExon 4: 23,919,196–23,920,989, 1,794 bases12345′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.2 kb of the gene's 3.9 kb; 615 of those bases code for the protein.

How a genome test reads RPL15

2

positions in RPL15 where ClinVar classes a change as pathogenic or likely pathogenic

2 of them (100%) fall in regions short reads find hard.

  • Low mappability (1 site)Regions where 100 bp or 250 bp reads cannot be placed uniquely.
  • Segmental duplications (2 sites)Copies of at least 1 kb sharing at least 90% identity with another part of the genome (paralogues, pseudogenes); reads may align to the wrong copy.

A whole genome covers all 3.9 kb of RPL15, introns included, not only the 2.2 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). RPL15 gene: ribosomal protein L15. Retrieved 17 October 2026, from https://dantelabs.com/genes/rpl15

Vancouver

Dante Labs. RPL15 gene: ribosomal protein L15 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/rpl15

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test