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Gene

DVL3

dishevelled segment polarity protein 3

Summary

Cytogenetic location
3q27.1
Coordinates
Chromosome 3: 184,155,377–184,173,614 (GRCh38)
Exons
15 exons across 18.2 kb
Protein
716 amino acids
Also known as
KIAA0208
MANE Select transcript
ENST00000313143.9NM_004423.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads DVL3 yet. The test sequences your whole genome, so your data includes it all the same.

How DVL3 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 3, with a bracket where DVL3 sits. DVL3 and 26 genes near it on chromosome 3, from 183,664,496 to 184,664,495.Chromosome 33q27.1p26.3p26.2p26.1p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p14.3p14.2p14.1p13p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13.11q13.12q13.13q13.2q13.31q13.32q13.33q21.1q21.2q21.3q22.1q22.2q22.3q23q24q25.1q25.2q25.31q25.32q25.33q26.1q26.2q26.31q26.32q26.33q27.1q27.2q27.3q28q29183.8 Mb184 Mb184.2 Mb184.4 Mb184.6 MbKLHL24: 183,635,602–183,693,117, forward strandKLHL24YEATS2: 183,697,748–183,812,809, forward strandYEATS2: 183,815,568–183,884,889, reverse strandMAP6D1: 183,815,881–183,825,612, reverse strandMAP6D1PARL: 183,826,489–183,884,933, reverse strandPARLABCC5: 183,919,934–184,018,307, reverse strandABCC5HTR3D: 184,031,544–184,039,369, forward strandHTR3DHTR3C: 184,053,047–184,060,673, forward strandHTR3CHTR3E: 184,097,064–184,106,995, forward strandHTR3EEIF2B5: 184,134,986–184,146,127, forward strandEIF2B5DVL3: 184,155,377–184,173,614, forward strandDVL3AP2M1: 184,174,689–184,184,214, forward strandAP2M1ABCF3: 184,186,095–184,194,451, forward strandABCF3VWA5B2: 184,228,996–184,242,342, forward strandVWA5B2ALG3: 184,242,301–184,249,571, reverse strandALG3EEF1AKMT4: 184,249,609–184,258,759, forward strandEEF1AKMT4EEF1AKMT4-ECE2: 184,249,695–184,293,031, forward strandCAMK2N2: 184,259,213–184,261,602, reverse strandCAMK2N2ECE2: 184,275,531–184,293,031, forward strandPSMD2: 184,299,157–184,309,054, forward strandEIF4G1: 184,314,490–184,335,358, forward strandFAM131A: 184,335,916–184,348,421, forward strandFAM131ACLCN2: 184,346,185–184,363,274, reverse strandCLCN2POLR2H: 184,360,856–184,368,596, forward strandPOLR2HTHPO: 184,367,389–184,381,968, reverse strandTHPOCHRD: 184,379,381–184,390,736, forward strandEPHB3: 184,561,751–184,582,408, forward strandEPHB3Diagram of DVL3: 15 exons on the forward strand of chromosome 3Exon 13: 1 known disease-causing siteExon 14: 5 known disease-causing sitesExon 15: 2 known disease-causing sitesExon 1: 184,155,377–184,155,796, 420 basesExon 2: 184,163,657–184,163,726, 70 basesExon 3: 184,164,267–184,164,388, 122 basesExon 4: 184,164,492–184,164,601, 110 basesExon 5: 184,164,796–184,164,931, 136 basesExon 6: 184,165,113–184,165,206, 94 basesExon 7: 184,165,422–184,165,491, 70 basesExon 8: 184,166,126–184,166,265, 140 basesExon 9: 184,166,446–184,166,522, 77 basesExon 10: 184,166,606–184,166,673, 68 basesExon 11: 184,166,826–184,166,975, 150 basesExon 12: 184,167,580–184,167,711, 132 basesExon 13: 184,167,898–184,168,065, 168 basesExon 14: 184,170,006–184,170,221, 216 basesExon 15: 184,170,319–184,173,614, 3,296 bases12468101214155′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 5.3 kb of the gene's 18.2 kb; 2,151 of those bases code for the protein.

How a genome test reads DVL3

11

positions in DVL3 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 18.2 kb of DVL3, introns included, not only the 5.3 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). DVL3 gene: dishevelled segment polarity protein 3. Retrieved 17 October 2026, from https://dantelabs.com/genes/dvl3

Vancouver

Dante Labs. DVL3 gene: dishevelled segment polarity protein 3 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/dvl3

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