Gene
MYT1L
myelin transcription factor 1 like
- HGNC 7623(opens in a new tab)
- Ensembl gene ENSG00000186487(opens in a new tab)
- NCBI Gene 23040(opens in a new tab)
Summary
- Cytogenetic location
- 2p25.3
- Coordinates
- Chromosome 2: 1,789,113–2,331,275 (GRCh38)
- Exons
- 25 exons across 542.2 kb
- Protein
- 1,186 amino acids
- Also known as
- KIAA1106, NZF1, ZC2HC4B, ZC2H2C2
- MANE Select transcript
- ENST00000647738.2NM_001303052.2
- Locus type
- gene with protein product
- Very high
- Confident
- Low
- Very low
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Intellectual Disability
One of 233 genes linked to it
- 5 GenCC submitters rate it definitive or strong
How MYT1L is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
- Known disease-causing sites
- Stretches short reads find hard
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 7.1 kb of the gene's 542.2 kb; 3,561 of those bases code for the protein.
How a genome test reads MYT1L
65
positions in MYT1L where ClinVar classes a change as pathogenic or likely pathogenic
None of them falls in a region short reads find hard.
A whole genome covers all 542.2 kb of MYT1L, introns included, not only the 7.1 kb of exons.
Traits linked to MYT1L
The Human Phenotype Ontology lists these as features of the rare conditions MYT1L can cause. Each trait's page lists the other genes linked to it.
Abnormality of the nervous system
- Attention deficit
- Delayed ability to walk
- Delayed motor skills
- Delayed speech and language development
- Global developmental delay
- Intellectual disability
- Aggressive behavior
- Autism spectrum disorder
Show 27 more traits
- Delayed fine motor development
- Abnormal eating behavior
- Abnormality of coordination
- Difficulty sleeping
- Impulsivity
- Increased appetite
- IQ between 34 and 49
- Motor delay
- Repetitive movements
- Specific learning disability
- Abnormal temper tantrums
- Anxiety
- Brief seizures with staring spells
- Degeneration of cerebrum
- Epilepsy
- Focal impaired awareness seizure
- Intellectual disability, mild
- Intellectual disability, severe
- Polyembolokoilamania
- Poor eye contact
- Self-mutilation
- Tachyphagia
- Teeth grinding
- Thin corpus callosum
- Too much cerebrospinal fluid in the brain
- Ventriculomegaly
- Pauses in breathing while sleeping
Abnormality of head or neck
- Wide mouth
- Wide nasal base
- Wide nasal bridge
- Almond shaped eyes
- Bulbous nose
- Exaggerated cupid's bow
- Full cheeks
- Abnormally small head
Show 2 more traits
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
- The ACMG secondary findings list, SF v3.2.
- ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
Cite this page
Dante Labs. (n.d.). MYT1L gene: myelin transcription factor 1 like. Retrieved 17 October 2026, from https://dantelabs.com/genes/myt1l
Dante Labs. MYT1L gene: myelin transcription factor 1 like [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/myt1l
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