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Gene

WARS2

tryptophanyl tRNA synthetase 2, mitochondrial

Summary

Cytogenetic location
1p12
Coordinates
Chromosome 1: 119,031,216–119,140,653 (GRCh38)
Exons
6 exons across 109.4 kb
Protein
360 amino acids
Also known as
mtTrpRS
MANE Select transcript
ENST00000235521.5NM_015836.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Dystonia, Myotonia, Paroxysmal Dyskinesia

    • Inherited Dystonia

      Umbrella term covering inherited dystonias, including DYT-TOR1A early-onset generalized dystonia, DYT-THAP1, myoclonus-dystonia (SGCE) and KMT2B-related dystonia.

      • 1 GenCC submitter rates it definitive or strong

How WARS2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 1, with a bracket where WARS2 sits. WARS2 and 4 genes near it on chromosome 1, from 118,585,935 to 119,585,934.Chromosome 11p12p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q44118.6 Mb118.8 Mb119 Mb119.2 Mb119.4 MbTBX15: 118,883,046–118,989,556, reverse strandTBX15WARS2: 119,031,216–119,140,653, reverse strandWARS2HAO2: 119,368,727–119,394,258, forward strandHAO2HSD3B2: 119,413,725–119,453,802, forward strandHSD3B2HSD3B1: 119,493,057–119,529,426, forward strandHSD3B1Diagram of WARS2: 6 exons on the reverse strand of chromosome 1Exon 6: 5 known disease-causing sitesExon 5: 3 known disease-causing sitesExon 3: 1 known disease-causing siteExon 2: 4 known disease-causing sitesExon 1: 1 known disease-causing siteExon 6: 119,031,216–119,033,359, 2,144 basesExon 5: 119,034,095–119,034,213, 119 basesExon 4: 119,042,264–119,042,349, 86 basesExon 3: 119,045,582–119,045,662, 81 basesExon 2: 119,076,350–119,076,607, 258 basesExon 1: 119,140,555–119,140,653, 99 bases6543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.8 kb of the gene's 109.4 kb; 1,083 of those bases code for the protein.

How a genome test reads WARS2

15

positions in WARS2 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 109.4 kb of WARS2, introns included, not only the 2.8 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). WARS2 gene: tryptophanyl tRNA synthetase 2, mitochondrial. Retrieved 17 October 2026, from https://dantelabs.com/genes/wars2

Vancouver

Dante Labs. WARS2 gene: tryptophanyl tRNA synthetase 2, mitochondrial [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/wars2

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