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Gene

NRAS

NRAS proto-oncogene, GTPase

Summary

Cytogenetic location
1p13.2
Coordinates
Chromosome 1: 114,704,469–114,716,771 (GRCh38)
Exons
7 exons across 12.3 kb
Protein
189 amino acids
Inheritance
Autosomal dominant
Also known as
N-ras
MANE Select transcript
ENST00000369535.5NM_002524.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Noonan Syndrome

    • Autosomal dominant

      Noonan Syndrome (NS) is characterized by short stature, typical facial dysmorphism and congenital heart defects.

      • ClinGen rates the link definitive
      • 5 GenCC submitters rate it definitive or strong
      What knowing changes

      Cardiac surveillance, developmental support, growth hormone therapy, genetic counseling, MEK inhibitor trials

    • Noonan Syndrome and Noonan-Related Syndromes

      A group of RAS pathway conditions, including Noonan, Costello, cardiofaciocutaneous and Legius syndromes, with variable heart defects, short stature and distinctive facial features.

      • ClinGen rates the link definitive
      • 5 GenCC submitters rate it definitive or strong
      What knowing changes

      Knowing about it supports heart, growth and developmental assessment.

Broader groupings

  • Hypertrophic Cardiomyopathy

    • Autosomal dominant

      One of 62 genes linked to it

      A condition in which the myocardium is hypertrophied without an obvious cause. The hypertrophy is generally asymmetric and may be associated with obstruction of the ventricular outflow tract.

      • ClinGen rates the link definitive
      • 5 GenCC submitters rate it definitive or strong
      What knowing changes

      Beta-blockers, non-dihydropyridine calcium channel blockers, activity restriction, genetic counseling

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

How NRAS is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
  • Variants with a page
Chromosome 1, with a bracket where NRAS sits. NRAS and 9 genes near it on chromosome 1, from 114,210,620 to 115,210,619.Chromosome 11p13.2p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q44114.4 Mb114.6 Mb114.8 Mb115 Mb115.2 MbTRIM33: 114,392,781–114,511,244, reverse strandTRIM33BCAS2: 114,547,043–114,581,725, reverse strandBCAS2DENND2C: 114,582,848–114,670,451, reverse strandDENND2CAMPD1: 114,673,090–114,695,620, reverse strandAMPD1NRAS: 114,704,469–114,716,771, reverse strandNRASCSDE1: 114,716,913–114,758,704, reverse strandCSDE1SIKE1: 114,769,479–114,780,706, reverse strandSIKE1SYCP1: 114,854,836–114,995,370, forward strandSYCP1TSHB: 115,029,826–115,034,302, forward strandTSHBTSPAN2: 115,047,056–115,089,528, reverse strandTSPAN2Diagram of NRAS: 7 exons on the reverse strand of chromosome 1Exon 4: 1 known disease-causing siteExon 3: 8 known disease-causing sitesExon 2: 6 known disease-causing sitesExon 7: 114,704,469–114,708,050, 3,582 basesExon 6: 114,708,154–114,708,192, 39 basesExon 5: 114,708,531–114,708,654, 124 basesExon 4: 114,709,569–114,709,728, 160 basesExon 3: 114,713,800–114,713,978, 179 bases. 1 variant with a page in exon 3. List themExon 2: 114,716,050–114,716,177, 128 basesExon 1: 114,716,658–114,716,771, 114 bases76543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.3 kb of the gene's 12.3 kb; 570 of those bases code for the protein.

How a genome test reads NRAS

15

positions in NRAS where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 12.3 kb of NRAS, introns included, not only the 4.3 kb of exons.

Variants with a page (1)

The NRAS variants with a page here, most review stars first. Each page describes ClinVar's public record of the variant, never a result.

VariantHGVS c.Exon or intronPosition (GRCh38)ClinVar classificationReview status
T58Ic.173C>TExon 3114,713,917Pathogenic3 stars out of 4 reviewed by expert panel

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). NRAS gene: NRAS proto-oncogene, GTPase. Retrieved 16 October 2026, from https://dantelabs.com/genes/nras

Vancouver

Dante Labs. NRAS gene: NRAS proto-oncogene, GTPase [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/nras

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