Gene
FEM1B
fem-1 homolog B
- HGNC 3649↗(opens in a new tab)
- Ensembl gene ENSG00000169018↗(opens in a new tab)
- NCBI Gene 10116↗(opens in a new tab)
Summary
- Cytogenetic location
- 15q23
- Coordinates
- Chromosome 15: 68,277,745–68,295,862 (GRCh38)
- Exons
- 2 exons across 18.1 kb
- Protein
- 627 amino acids
- MANE Select transcript
- ENST00000306917.5NM_015322.5
- Locus type
- gene with protein product
- Very high
- Confident
- Low
- Very low
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How FEM1B is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
- Stretches short reads find hard
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 7.2 kb of the gene's 18.1 kb; 1,884 of those bases code for the protein.
Traits linked to FEM1B
The Human Phenotype Ontology lists these as features of the rare conditions FEM1B can cause. Each trait's page lists the other genes linked to it.
Abnormality of the nervous system
- Central sleep apnea
- Cerebral palsy
- Congenital encephalopathy
- Delayed ability to walk
- Difficulty articulating speech
- Echoing another person's speech
- Global developmental delay
- Increased reflexes
Show 26 more traits
- Inflexible adherence to routines
- Intellectual disability
- IQ between 34 and 49
- Irritability
- Lack of coordination of movement
- Low frustration tolerance
- Mild expressive language delay
- Self-biting
- Waddling gait
- Wide based walk
- Aggressive behavior
- Anxiety
- Cerebellar vermis hypoplasia
- Delayed ability to sit
- Delayed fine motor development
- Delayed speech and language development
- Self-injurious behavior
- Small cerebellum
- Thin corpus callosum
- Underdevelopment of part of brain called corpus callosum
- Degeneration of cerebrum
- Fluid-filled cyst in spinal cord
- Fluid-filled sac located in membrane surrounding brain or spinal cord
- Head-banging
- Hypoplasia of the pons
- Simplified gyral pattern
Abnormality of head or neck
- Big calvaria
- Flat back of skull
- Long face
- Posterior plagiocephaly
- Prominent forehead
- Prominent nose
- Eye folds
- Wide mouth
Show 15 more traits
- Abnormally large tongue
- Blocked tear duct
- Corners of eye widely separated
- Depressed nasal bridge
- Downturned corners of mouth
- Downward slanting of the opening between the eyelids
- Gap between teeth
- Long philtrum
- Low hanging columella
- Monobrow
- Pointed chin
- Short philtrum
- Smooth philtrum
- Tongue tied
- Wide nasal bridge
Abnormality of the musculoskeletal system
- Hunched back
- Involuntary muscle stiffness, contraction, or spasm
- Low muscle tone in trunk
- Pigeon chest
- Spasticity and rigidity of muscles
- Tired easily
- Low muscle tone
- Scoliosis
Show 3 more traits
Abnormality of the digestive system
- Chronic constipation
- Diarrhea
- Eosinophilic infiltration of the esophagus
- Feeding difficulties
- Poor suck
- Vomiting
- Inguinal hernia
- Acid reflux
Show 2 more traits
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
Cite this page
Dante Labs. (n.d.). FEM1B gene: fem-1 homolog B. Retrieved 17 October 2026, from https://dantelabs.com/genes/fem1b
Dante Labs. FEM1B gene: fem-1 homolog B [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/fem1b
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