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Gene

KPTN

kaptin, actin binding protein

Summary

Cytogenetic location
19q13.32
Coordinates
Chromosome 19: 47,475,150–47,484,219 (GRCh38)
Exons
12 exons across 9.1 kb
Protein
436 amino acids
Also known as
2E4, KICS4
MANE Select transcript
ENST00000338134.8NM_007059.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads KPTN yet. The test sequences your whole genome, so your data includes it all the same.

How KPTN is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 19, with a bracket where KPTN sits. KPTN and 24 genes near it on chromosome 19, from 46,979,685 to 47,979,684.Chromosome 1919q13.32p13.3p13.2p13.13p13.12p13.11p12p11q11q12q13.11q13.12q13.13q13.2q13.31q13.32q13.33q13.41q13.42q13.4347 Mb47.2 Mb47.4 Mb47.6 Mb47.8 MbARHGAP35: 46,860,433–47,005,077, forward strandARHGAP35NPAS1: 47,019,474–47,047,242, forward strandNPAS1TMEM160: 47,045,909–47,048,650, reverse strandTMEM160ZC3H4: 47,064,187–47,113,776, reverse strandZC3H4SAE1: 47,113,274–47,210,636, forward strandSAE1BBC3: 47,220,822–47,233,019, reverse strandBBC3CCDC9: 47,255,980–47,274,055, forward strandCCDC9INAFM1: 47,274,373–47,277,755, forward strandINAFM1C5AR1: 47,290,023–47,322,075, forward strandC5AR1C5AR2: 47,332,148–47,347,329, forward strandC5AR2DHX34: 47,349,280–47,383,255, forward strandDHX34MEIS3: 47,403,117–47,419,530, reverse strandMEIS3SLC8A2: 47,428,017–47,472,184, reverse strandSLC8A2KPTN: 47,475,150–47,484,219, reverse strandKPTNNAPA: 47,484,530–47,515,122, reverse strandNAPAZNF541: 47,520,638–47,573,148, reverse strandZNF541BICRA: 47,608,196–47,703,277, forward strandBICRAEHD2: 47,713,388–47,745,089, forward strandEHD2NOP53: 47,745,481–47,758,208, forward strandNOP53SELENOW: 47,778,508–47,784,686, forward strandSELENOWTPRX1: 47,801,232–47,819,051, reverse strandTPRX1CRX: 47,819,779–47,843,330, forward strandCRXTPRX2: 47,859,235–47,861,721, forward strandTPRX2SULT2A1: 47,870,327–47,886,479, reverse strandSULT2A1BSPH1: 47,968,046–47,992,170, reverse strandBSPH1Diagram of KPTN: 12 exons on the reverse strand of chromosome 19Exon 11: 1 known disease-causing siteExon 9: 1 known disease-causing siteExon 8: 6 known disease-causing sitesExon 7: 2 known disease-causing sitesExon 6: 2 known disease-causing sitesExon 4: 1 known disease-causing siteExon 3: 1 known disease-causing siteExon 1: 1 known disease-causing siteExon 12: 47,475,150–47,475,544, 395 basesExon 11: 47,476,532–47,476,714, 183 basesExon 10: 47,476,803–47,476,938, 136 basesExon 9: 47,477,706–47,477,781, 76 basesExon 8: 47,479,863–47,479,940, 78 basesExon 7: 47,480,298–47,480,407, 110 basesExon 6: 47,480,760–47,480,833, 74 basesExon 5: 47,480,958–47,481,033, 76 basesExon 4: 47,483,161–47,483,215, 55 basesExon 3: 47,483,295–47,483,379, 85 basesExon 2: 47,483,502–47,483,584, 83 basesExon 1: 47,483,935–47,484,219, 285 bases1211109876543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.6 kb of the gene's 9.1 kb; 1,311 of those bases code for the protein.

How a genome test reads KPTN

22

positions in KPTN where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 9.1 kb of KPTN, introns included, not only the 1.6 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). KPTN gene: kaptin, actin binding protein. Retrieved 17 October 2026, from https://dantelabs.com/genes/kptn

Vancouver

Dante Labs. KPTN gene: kaptin, actin binding protein [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/kptn

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