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Gene

TWIST2

twist family bHLH transcription factor 2

Summary

Cytogenetic location
2q37.3
Coordinates
Chromosome 2: 238,848,085–238,910,534 (GRCh38)
Exons
2 exons across 62.5 kb
Protein
160 amino acids
Also known as
DERMO1, Dermo-1, bHLHa39
MANE Select transcript
ENST00000612363.2NM_001271893.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads TWIST2 yet. The test sequences your whole genome, so your data includes it all the same.

How TWIST2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 2, with a bracket where TWIST2 sits. TWIST2 and 3 genes near it on chromosome 2, from 238,379,310 to 239,379,309.Chromosome 22q37.3p25.3p25.2p25.1p24.3p24.2p24.1p23.3p23.2p23.1p22.3p22.2p22.1p21p16.3p16.2p16.1p15p14p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13q14.1q14.2q14.3q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q31.1q31.2q31.3q32.1q32.2q32.3q33.1q33.2q33.3q34q35q36.1q36.2q36.3q37.1q37.2q37.3238.4 Mb238.6 Mb238.8 Mb239 Mb239.2 MbIFT54: 238,320,441–238,402,114, forward strandIFT54ASB1: 238,426,742–238,452,250, forward strandASB1TWIST2: 238,848,085–238,910,534, forward strandTWIST2HDAC4: 239,048,168–239,401,661, reverse strandHDAC4Diagram of TWIST2: 2 exons on the forward strand of chromosome 2Exon 1: 1 known disease-causing siteExon 1: 238,848,085–238,848,733, 649 basesExon 2: 238,909,842–238,910,534, 693 bases125′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.3 kb of the gene's 62.5 kb; 483 of those bases code for the protein.

How a genome test reads TWIST2

1

position in TWIST2 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 62.5 kb of TWIST2, introns included, not only the 1.3 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). TWIST2 gene: twist family bHLH transcription factor 2. Retrieved 16 October 2026, from https://dantelabs.com/genes/twist2

Vancouver

Dante Labs. TWIST2 gene: twist family bHLH transcription factor 2 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/twist2

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