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Gene

TBCK

TBC1 domain containing kinase

Summary

Cytogenetic location
4q24
Coordinates
Chromosome 4: 106,041,599–106,316,209 (GRCh38)
Exons
26 exons across 274.6 kb
Protein
893 amino acids
Also known as
MGC16169, HSPC302, Fy-1, FERRY1
MANE Select transcript
ENST00000394708.7NM_001163435.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads TBCK yet. The test sequences your whole genome, so your data includes it all the same.

How TBCK is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 4, with a bracket where TBCK sits. TBCK and 6 genes near it on chromosome 4, from 105,678,904 to 106,678,903.Chromosome 44q24p16.3p16.2p16.1p15.33p15.32p15.31p15.2p15.1p14p13p12p11q11q12q13.1q13.2q13.3q21.1q21.21q21.22q21.23q21.3q22.1q22.2q22.3q23q24q25q26q27q28.1q28.2q28.3q31.1q31.21q31.22q31.23q31.3q32.1q32.2q32.3q33q34.1q34.2q34.3q35.1q35.2105.8 Mb106 Mb106.2 Mb106.4 Mb106.6 MbARHGEF38: 105,552,484–105,708,093, forward strandARHGEF38INTS12: 105,682,014–105,895,986, reverse strandINTS12GSTCD: 105,708,774–105,849,570, forward strandGSTCDNPNT: 105,894,775–106,115,115, forward strandNPNTTBCK: 106,041,599–106,316,209, reverse strandTBCKAIMP1: 106,315,544–106,349,836, forward strandAIMP1GIMD1: 106,357,392–106,368,778, reverse strandGIMD1Diagram of TBCK: 26 exons on the reverse strand of chromosome 4Exon 25: 2 known disease-causing sitesExon 24: 4 known disease-causing sitesExon 23: 3 known disease-causing sitesExon 22: 3 known disease-causing sitesExon 21: 1 known disease-causing siteExon 20: 2 known disease-causing sitesExon 19: 1 known disease-causing siteExon 17: 2 known disease-causing sitesExon 15: 2 known disease-causing sitesExon 14: 2 known disease-causing sitesExon 12: 1 known disease-causing siteExon 11: 3 known disease-causing sitesExon 10: 3 known disease-causing sitesExon 9: 2 known disease-causing sitesExon 8: 2 known disease-causing sitesExon 6: 5 known disease-causing sitesExon 4: 4 known disease-causing sitesExon 3: 2 known disease-causing sitesExon 2: 1 known disease-causing siteExon 26: 106,041,599–106,046,680, 5,082 basesExon 25: 106,095,482–106,095,641, 160 basesExon 24: 106,116,203–106,116,378, 176 basesExon 23: 106,171,095–106,171,270, 176 basesExon 22: 106,193,609–106,193,770, 162 basesExon 21: 106,194,718–106,194,754, 37 basesExon 20: 106,212,750–106,212,835, 86 basesExon 19: 106,230,363–106,230,446, 84 basesExon 18: 106,231,729–106,231,779, 51 basesExon 17: 106,232,938–106,233,064, 127 basesExon 16: 106,233,588–106,233,650, 63 basesExon 15: 106,235,269–106,235,367, 99 basesExon 14: 106,236,390–106,236,519, 130 basesExon 13: 106,236,759–106,236,808, 50 basesExon 12: 106,242,470–106,242,569, 100 basesExon 11: 106,244,626–106,244,764, 139 basesExon 10: 106,247,139–106,247,287, 149 basesExon 9: 106,248,245–106,248,306, 62 basesExon 8: 106,248,921–106,248,982, 62 basesExon 7: 106,250,418–106,250,478, 61 basesExon 6: 106,251,866–106,252,007, 142 basesExon 5: 106,260,437–106,260,510, 74 basesExon 4: 106,262,098–106,262,212, 115 basesExon 3: 106,295,094–106,295,166, 73 basesExon 2: 106,308,768–106,308,989, 222 basesExon 1: 106,315,931–106,316,209, 279 bases2625201510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 8 kb of the gene's 274.6 kb; 2,682 of those bases code for the protein.

How a genome test reads TBCK

64

positions in TBCK where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 274.6 kb of TBCK, introns included, not only the 8 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). TBCK gene: TBC1 domain containing kinase. Retrieved 17 October 2026, from https://dantelabs.com/genes/tbck

Vancouver

Dante Labs. TBCK gene: TBC1 domain containing kinase [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/tbck

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