Gene
FREM2
FRAS1 related extracellular matrix 2
- HGNC 25396(opens in a new tab)
- Ensembl gene ENSG00000150893(opens in a new tab)
- NCBI Gene 341640(opens in a new tab)
Summary
- Cytogenetic location
- 13q13.3
- Coordinates
- Chromosome 13: 38,687,077–38,887,131 (GRCh38)
- Exons
- 24 exons across 200.1 kb
- Protein
- 3,169 amino acids
- Also known as
- DKFZp686J0811
- MANE Select transcript
- ENST00000280481.9NM_207361.6
- Locus type
- gene with protein product
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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No Genome Test report reads FREM2 yet. The test sequences your whole genome, so your data includes it all the same.
How FREM2 is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
- Known disease-causing sites
- Stretches short reads find hard
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 16.1 kb of the gene's 200.1 kb; 9,510 of those bases code for the protein.
How a genome test reads FREM2
48
positions in FREM2 where ClinVar classes a change as pathogenic or likely pathogenic
None of them falls in a region short reads find hard.
A whole genome covers all 200.1 kb of FREM2, introns included, not only the 16.1 kb of exons.
Traits linked to FREM2
The Human Phenotype Ontology lists these as features of the rare conditions FREM2 can cause. Each trait's page lists the other genes linked to it.
Abnormality of the digestive system
- Absent anus
- Anorectal anomaly
- Narrowing of anal opening
- Abnormal anus position
- Intestinal malrotation
- Omphalocele
- Rectal atresia
- Umbilical hernia
Show 1 more trait
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
Cite this page
Dante Labs. (n.d.). FREM2 gene: FRAS1 related extracellular matrix 2. Retrieved 16 October 2026, from https://dantelabs.com/genes/frem2
Dante Labs. FREM2 gene: FRAS1 related extracellular matrix 2 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/frem2
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