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Gene

RTTN

rotatin

Summary

Cytogenetic location
18q22.2
Coordinates
Chromosome 18: 70,003,031–70,205,687 (GRCh38)
Exons
49 exons across 202.7 kb
Protein
2,226 amino acids
Also known as
DKFZP434G145
MANE Select transcript
ENST00000640769.2NM_173630.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads RTTN yet. The test sequences your whole genome, so your data includes it all the same.

How RTTN is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 18, with a bracket where RTTN sits. RTTN and 3 genes near it on chromosome 18, from 69,604,359 to 70,604,358.Chromosome 1818q22.2p11.32p11.31p11.23p11.22p11.21p11.1q11.1q11.2q12.1q12.2q12.3q21.1q21.2q21.31q21.32q21.33q22.1q22.2q22.3q2369.8 Mb70 Mb70.2 Mb70.4 Mb70.6 MbDOK6: 69,400,741–69,849,087, forward strandDOK6CD226: 69,831,158–69,961,803, reverse strandCD226RTTN: 70,003,031–70,205,687, reverse strandRTTNSOCS6: 70,288,876–70,330,199, forward strandSOCS6Diagram of RTTN: 49 exons on the reverse strand of chromosome 18Exon 44: 1 known disease-causing siteExon 43: 1 known disease-causing siteExon 42: 1 known disease-causing siteExon 30: 2 known disease-causing sitesExon 27: 1 known disease-causing siteExon 26: 1 known disease-causing siteExon 23: 2 known disease-causing sitesExon 14: 1 known disease-causing siteExon 13: 1 known disease-causing siteExon 12: 1 known disease-causing siteExon 9: 1 known disease-causing siteExon 7: 1 known disease-causing siteExon 6: 1 known disease-causing siteExon 4: 3 known disease-causing sitesExon 2: 2 known disease-causing sitesExon 49: 70,003,031–70,004,236, 1,206 basesExon 48: 70,005,198–70,005,267, 70 basesExon 47: 70,006,381–70,006,484, 104 basesExon 46: 70,017,407–70,017,674, 268 basesExon 45: 70,020,615–70,020,817, 203 basesExon 44: 70,024,722–70,024,848, 127 basesExon 43: 70,028,724–70,028,801, 78 basesExon 42: 70,030,012–70,030,109, 98 basesExon 41: 70,030,876–70,030,981, 106 basesExon 40: 70,047,971–70,048,188, 218 basesExon 39: 70,051,411–70,051,548, 138 basesExon 38: 70,054,131–70,054,284, 154 basesExon 37: 70,057,742–70,057,832, 91 basesExon 36: 70,059,850–70,060,042, 193 basesExon 35: 70,065,829–70,065,922, 94 basesExon 34: 70,073,906–70,073,994, 89 basesExon 33: 70,075,352–70,075,541, 190 basesExon 32: 70,086,613–70,086,684, 72 basesExon 31: 70,087,989–70,088,147, 159 basesExon 30: 70,092,110–70,092,220, 111 basesExon 29: 70,092,676–70,092,804, 129 basesExon 28: 70,109,498–70,109,717, 220 basesExon 27: 70,114,445–70,114,599, 155 basesExon 26: 70,121,556–70,121,700, 145 basesExon 25: 70,127,502–70,127,741, 240 basesExon 24: 70,128,358–70,128,546, 189 basesExon 23: 70,134,473–70,134,541, 69 basesExon 22: 70,135,184–70,135,280, 97 basesExon 21: 70,139,599–70,139,716, 118 basesExon 20: 70,140,100–70,140,188, 89 basesExon 19: 70,142,288–70,142,387, 100 basesExon 18: 70,145,612–70,145,783, 172 basesExon 17: 70,148,901–70,149,037, 137 basesExon 16: 70,149,971–70,150,087, 117 basesExon 15: 70,150,608–70,150,733, 126 basesExon 14: 70,166,062–70,166,188, 127 basesExon 13: 70,166,919–70,167,031, 113 basesExon 12: 70,168,855–70,169,067, 213 basesExon 11: 70,176,675–70,176,845, 171 basesExon 10: 70,188,108–70,188,223, 116 basesExon 9: 70,190,538–70,190,719, 182 basesExon 8: 70,193,288–70,193,453, 166 basesExon 7: 70,196,501–70,196,648, 148 basesExon 6: 70,197,624–70,197,738, 115 basesExon 5: 70,199,414–70,199,504, 91 basesExon 4: 70,201,894–70,201,983, 90 basesExon 3: 70,204,086–70,204,263, 178 basesExon 2: 70,205,128–70,205,315, 188 basesExon 1: 70,205,628–70,205,687, 60 bases494540353025201510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 7.8 kb of the gene's 202.7 kb; 6,681 of those bases code for the protein.

How a genome test reads RTTN

28

positions in RTTN where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 202.7 kb of RTTN, introns included, not only the 7.8 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). RTTN gene: rotatin. Retrieved 17 October 2026, from https://dantelabs.com/genes/rttn

Vancouver

Dante Labs. RTTN gene: rotatin [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/rttn

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