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Gene

WAC

WW domain containing adaptor with coiled-coil

Summary

Cytogenetic location
10p12.1
Coordinates
Chromosome 10: 28,533,118–28,623,112 (GRCh38)
Exons
14 exons across 90 kb
Protein
647 amino acids
Also known as
Wwp4, FLJ31290, PRO1741, BM-016, MGC10753
MANE Select transcript
ENST00000354911.9NM_016628.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads WAC yet. The test sequences your whole genome, so your data includes it all the same.

How WAC is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 10, with a bracket where WAC sits. WAC and 2 genes near it on chromosome 10, from 28,078,115 to 29,078,114.Chromosome 1010p12.1p15.3p15.2p15.1p14p13p12.33p12.32p12.31p12.2p12.1p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.31q23.32q23.33q24.1q24.2q24.31q24.32q24.33q25.1q25.2q25.3q26.11q26.12q26.13q26.2q26.328.2 Mb28.4 Mb28.6 Mb28.8 Mb29 MbMPP7: 28,050,993–28,335,290, reverse strandMPP7WAC: 28,533,118–28,623,112, forward strandWACBAMBI: 28,677,510–28,684,890, forward strandBAMBIDiagram of WAC: 14 exons on the forward strand of chromosome 10Exon 1: 1 known disease-causing siteExon 2: 1 known disease-causing siteExon 3: 6 known disease-causing sitesExon 4: 4 known disease-causing sitesExon 5: 6 known disease-causing sitesExon 6: 3 known disease-causing sitesExon 7: 4 known disease-causing sitesExon 8: 4 known disease-causing sitesExon 9: 2 known disease-causing sitesExon 10: 6 known disease-causing sitesExon 11: 6 known disease-causing sitesExon 12: 3 known disease-causing sitesExon 13: 5 known disease-causing sitesExon 1: 28,533,118–28,533,620, 503 basesExon 2: 28,533,998–28,534,034, 37 basesExon 3: 28,535,562–28,535,757, 196 basesExon 4: 28,583,399–28,583,505, 107 basesExon 5: 28,589,736–28,589,851, 116 basesExon 6: 28,590,720–28,590,832, 113 basesExon 7: 28,595,733–28,596,041, 309 basesExon 8: 28,608,186–28,608,431, 246 basesExon 9: 28,610,699–28,610,821, 123 basesExon 10: 28,611,774–28,611,922, 149 basesExon 11: 28,614,567–28,614,685, 119 basesExon 12: 28,616,173–28,616,362, 190 basesExon 13: 28,617,657–28,617,784, 128 basesExon 14: 28,619,537–28,623,112, 3,576 bases1510145′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 5.9 kb of the gene's 90 kb; 1,944 of those bases code for the protein.

How a genome test reads WAC

59

positions in WAC where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 90 kb of WAC, introns included, not only the 5.9 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). WAC gene: WW domain containing adaptor with coiled-coil. Retrieved 16 October 2026, from https://dantelabs.com/genes/wac

Vancouver

Dante Labs. WAC gene: WW domain containing adaptor with coiled-coil [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/wac

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