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Gene

PRKG2

protein kinase cGMP-dependent 2

Summary

Cytogenetic location
4q21.21
Coordinates
Chromosome 4: 81,087,375–81,215,222 (GRCh38)
Exons
19 exons across 127.8 kb
Protein
762 amino acids
Also known as
cGKII, PRKGR2, PKG2
MANE Select transcript
ENST00000264399.6NM_006259.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads PRKG2 yet. The test sequences your whole genome, so your data includes it all the same.

How PRKG2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 4, with a bracket where PRKG2 sits. PRKG2 and 3 genes near it on chromosome 4, from 80,651,299 to 81,651,298.Chromosome 44q21.21p16.3p16.2p16.1p15.33p15.32p15.31p15.2p15.1p14p13p12p11q11q12q13.1q13.2q13.3q21.1q21.21q21.22q21.23q21.3q22.1q22.2q22.3q23q24q25q26q27q28.1q28.2q28.3q31.1q31.21q31.22q31.23q31.3q32.1q32.2q32.3q33q34.1q34.2q34.3q35.1q35.280.8 Mb81 Mb81.2 Mb81.4 Mb81.6 MbCFAP299: 80,335,730–80,963,750, forward strandCFAP299BMP3: 81,030,632–81,057,627, forward strandBMP3PRKG2: 81,087,375–81,215,222, reverse strandPRKG2RASGEF1B: 81,426,393–82,044,244, reverse strandRASGEF1BDiagram of PRKG2: 19 exons on the reverse strand of chromosome 4Exon 13: 1 known disease-causing siteExon 12: 1 known disease-causing siteExon 8: 1 known disease-causing siteExon 19: 81,087,375–81,089,803, 2,429 basesExon 18: 81,092,386–81,092,452, 67 basesExon 17: 81,104,370–81,104,432, 63 basesExon 16: 81,105,813–81,105,935, 123 basesExon 15: 81,110,448–81,110,611, 164 basesExon 14: 81,135,155–81,135,296, 142 basesExon 13: 81,137,393–81,137,482, 90 basesExon 12: 81,140,533–81,140,669, 137 basesExon 11: 81,142,794–81,142,947, 154 basesExon 10: 81,144,232–81,144,330, 99 basesExon 9: 81,148,884–81,148,952, 69 basesExon 8: 81,151,960–81,152,054, 95 basesExon 7: 81,153,644–81,153,721, 78 basesExon 6: 81,167,161–81,167,224, 64 basesExon 5: 81,169,663–81,169,768, 106 basesExon 4: 81,171,691–81,171,804, 114 basesExon 3: 81,174,793–81,174,959, 167 basesExon 2: 81,204,587–81,205,060, 474 basesExon 1: 81,214,936–81,215,222, 287 bases191816141210864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.9 kb of the gene's 127.8 kb; 2,289 of those bases code for the protein.

How a genome test reads PRKG2

4

positions in PRKG2 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 127.8 kb of PRKG2, introns included, not only the 4.9 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). PRKG2 gene: protein kinase cGMP-dependent 2. Retrieved 17 October 2026, from https://dantelabs.com/genes/prkg2

Vancouver

Dante Labs. PRKG2 gene: protein kinase cGMP-dependent 2 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/prkg2

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