Skip to content
Use your HSA or FSA funds
Sequence your genome (opens in a new tab)

Gene

TPM2

tropomyosin 2

Summary

Cytogenetic location
9p13.3
Coordinates
Chromosome 9: 35,682,932–35,689,925 (GRCh38)
Exons
9 exons across 7 kb
Protein
284 amino acids
Also known as
DA1, NEM4
Previous symbols
AMCD1
MANE Select transcript
ENST00000645482.3NM_003289.4
Locus type
Protein-coding
  • Very high
  • Confident
  • Low
  • Very low

Curated report relevant to this gene

  • Congenital Myopathies

    • Nemaline myopathy

      A congenital myopathy defined by rod-shaped structures in muscle fibers, most often caused by NEB or ACTA1 variants.

      • 2 GenCC submitters rate it definitive or strong

How TPM2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 9, with a bracket where TPM2 sits. TPM2 and 29 genes near it on chromosome 9, from 35,186,429 to 36,186,428.Chromosome 99p13.3p24.3p24.2p24.1p23p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q13q21.11q21.12q21.13q21.2q21.31q21.32q21.33q22.1q22.2q22.31q22.32q22.33q31.1q31.2q31.3q32q33.1q33.2q33.3q34.11q34.12q34.13q34.2q34.335.2 Mb35.4 Mb35.6 Mb35.8 Mb36 MbUNC13B: 35,161,829–35,405,339, forward strandUNC13BRUSC2: 35,489,670–35,562,266, forward strandRUSC2CIMIP2B: 35,561,831–35,563,914, reverse strandCIMIP2BTESK1: 35,605,235–35,610,328, forward strandTESK1CD72: 35,609,965–35,646,810, reverse strandCD72SIT1: 35,649,288–35,650,970, reverse strandRMRP: 35,657,750–35,658,019, reverse strandCCDC107: 35,658,277–35,661,524, forward strandCCDC107ARHGEF39: 35,658,874–35,675,866, reverse strandARHGEF39CA9: 35,673,898–35,681,159, forward strandCA9TPM2: 35,682,932–35,689,925, reverse strandTPM2TLN1: 35,696,925–35,732,212, reverse strandCREB3: 35,732,296–35,738,887, forward strandCREB3GBA2: 35,734,577–35,749,986, reverse strandGBA2RGP1: 35,748,613–35,759,600, forward strandRGP1MSMP: 35,752,990–35,756,613, reverse strandNPR2: 35,791,003–35,809,732, forward strandNPR2SPAG8: 35,808,045–35,812,272, reverse strandSPAG8HINT2: 35,812,960–35,815,354, reverse strandHINT2: 35,812,960–35,828,732, reverse strandTMEM8B: 35,814,451–35,865,518, forward strandFAM221B: 35,816,391–35,828,747, reverse strandOR13J1: 35,869,463–35,870,401, reverse strandOR13J1HRCT1: 35,906,202–35,907,136, forward strandHRCT1SPAAR: 35,909,488–35,937,153, forward strandSPAAROR2S2: 35,957,108–35,958,154, reverse strandOR2S2OR13C7: 36,002,909–36,003,867, reverse strandOR13C7RECK: 36,036,896–36,124,457, forward strandRECKGLIPR2: 36,136,417–36,163,913, forward strandGLIPR2CCIN: 36,165,751–36,172,384, forward strandCCINDiagram of TPM2: 9 exons on the reverse strand of chromosome 9Exon 9: 1 known disease-causing siteExon 7: 1 known disease-causing siteExon 6: 2 known disease-causing sitesExon 4: 5 known disease-causing sitesExon 3: 5 known disease-causing sitesExon 2: 4 known disease-causing sitesExon 1: 5 known disease-causing sitesExon 9: 35,682,932–35,683,241, 310 basesExon 8: 35,684,246–35,684,315, 70 basesExon 7: 35,684,488–35,684,550, 63 basesExon 6: 35,684,732–35,684,807, 76 basesExon 5: 35,685,269–35,685,339, 71 basesExon 4: 35,685,434–35,685,551, 118 basesExon 3: 35,685,647–35,685,780, 134 basesExon 2: 35,689,146–35,689,271, 126 basesExon 1: 35,689,704–35,689,925, 222 bases9876543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.2 kb of the gene's 7 kb; 855 of those bases code for the protein.

Sequencing TPM2

27

positions in TPM2 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 7 kb of TPM2, introns included, not only the 1.2 kb of exons.

Genes linked to the same conditions

Traits linked to TPM2

The Human Phenotype Ontology lists these as features of the rare conditions TPM2 can cause. Each trait's page lists the other genes linked to it.

Abnormality of the musculoskeletal system

Show 53 more traits

Abnormality of limbs

Show 29 more traits

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-17: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.17-8666dff2.

Cite this page

APA

Dante Labs. (n.d.). TPM2 gene: tropomyosin 2. Retrieved 17 October 2026, from https://dantelabs.com/genes/tpm2

Vancouver

Dante Labs. TPM2 gene: tropomyosin 2 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/tpm2

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test