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Gene

COX7B

cytochrome c oxidase subunit 7B

Summary

Cytogenetic location
Xq21.1
Coordinates
Chromosome X: 77,899,468–77,907,376 (GRCh38)
Exons
3 exons across 7.9 kb
Protein
80 amino acids
MANE Select transcript
ENST00000650309.2NM_001866.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Microphthalmia, Anophthalmia & Coloboma

    • Syndromic Microphthalmia

      Microphthalmia occurring with features outside the eye, caused by changes in genes such as SOX2, OTX2, BCOR, STRA6 and BMP4.

      • 2 GenCC submitters rate it definitive or strong
      What knowing changes

      A genetic diagnosis guides checks for associated features, such as pituitary hormone problems with SOX2 or OTX2, and informs recurrence risk.

How COX7B is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome X, with a bracket where COX7B sits. COX7B and 8 genes near it on chromosome X, from 77,403,422 to 78,403,421.Chromosome XXq21.1p22.33p22.32p22.31p22.2p22.13p22.12p22.11p21.3p21.2p21.1p11.4p11.3p11.23p11.22p11.21p11.1q11.1q11.2q12q13.1q13.2q13.3q21.1q21.2q21.31q21.32q21.33q22.1q22.2q22.3q23q24q25q26.1q26.2q26.3q27.1q27.2q27.3q2877.6 Mb77.8 Mb78 Mb78.2 Mb78.4 MbFGF16: 77,447,388–77,457,278, forward strandFGF16ATRX: 77,504,862–77,786,233, reverse strandATRXMAGT1: 77,825,747–77,899,271, reverse strandMAGT1COX7B: 77,899,468–77,907,376, forward strandCOX7BATP7A: 77,910,688–78,050,395, forward strandATP7APGK1: 77,910,739–78,132,378, forward strandPGK1PGAM4: 77,967,949–77,969,638, reverse strandPGAM4TAF9B: 78,126,646–78,139,705, reverse strandTAF9BCYSLTR1: 78,270,496–78,327,845, reverse strandCYSLTR1Diagram of COX7B: 3 exons on the forward strand of chromosome XExon 1: 77,899,468–77,899,593, 126 basesExon 2: 77,902,643–77,902,767, 125 basesExon 3: 77,905,184–77,907,376, 2,193 bases1235′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.4 kb of the gene's 7.9 kb; 243 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). COX7B gene: cytochrome c oxidase subunit 7B. Retrieved 16 October 2026, from https://dantelabs.com/genes/cox7b

Vancouver

Dante Labs. COX7B gene: cytochrome c oxidase subunit 7B [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/cox7b

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